{"id":"W3030671769","doi":"10.1200/jco.2020.38.15_suppl.e16789","title":"Pembrolizumab in combination with the oncolytic virus pelareorep in patients progressing on systemic chemotherapy for advanced pancreatic adenocarcinoma: A phase II study.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Pembrolizumab; Oncolytic virus; Response Evaluation Criteria in Solid Tumors; Internal medicine; Progressive disease; Chemotherapy; Oncology; Gastroenterology; Adverse effect; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001478068,0.001161088,0.002329204,0.0003992047,0.0003528153,0.0007544711,0.0007075456,0.000936186,0.002218022],"category_scores_gemma":[0.0005378646,0.0006807723,0.001268332,0.0004596905,0.0007230958,0.0008113671,0.000287957,0.002485984,0.0006802826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007558413,"about_ca_system_score_gemma":0.00118989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000827732,"about_ca_topic_score_gemma":0.002154092,"domain_scores_codex":[0.999593,0.0001916143,0.0000209294,0.00006806601,0.00004141832,0.00008499192],"domain_scores_gemma":[0.9995657,0.00007580052,0.00008051681,0.00004548124,0.00002631997,0.0002061781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5259331,0.1692074,0.02009419,0.001702307,0.002157077,0.0007557076,0.0005972076,0.002687497,0.06943027,0.000369842,0.003672585,0.2033929],"study_design_scores_gemma":[0.4046322,0.5698373,0.01764554,0.00005202519,0.0005407656,0.0004621361,0.00008452843,0.001161105,0.00290207,0.0000962768,0.002564728,0.00002133007],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942542,0.002003887,0.000327789,0.0002781756,0.00007055166,0.001746514,0.0003055784,0.00003895768,0.0009743978],"genre_scores_gemma":[0.9911234,0.002454318,0.001368659,0.0006167317,0.0001475297,0.002149608,0.0008064894,0.00001715302,0.001316094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002329204,"threshold_uncertainty_score":0.007816851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06112290611267555,"score_gpt":0.4350794247038143,"score_spread":0.3739565185911388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}