{"id":"W3030748957","doi":"10.1016/j.cell.2020.05.042","title":"SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Respiratory viral infections research","field":"Medicine","cited_by":1667,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; American Lung Association; Cystic Fibrosis Foundation","keywords":"Biology; Respiratory tract; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Genetics; 2019-20 coronavirus outbreak; Reverse genetics; Respiratory system; Genome; Gene; Disease; Infectious disease (medical specialty); Pathology; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208418,0.0002348139,0.0002249472,0.0003599106,0.0002339452,0.0008826265,0.0002299853,0.0003632284,0.002157028],"category_scores_gemma":[0.0001504844,0.0002833601,0.000206376,0.000169562,0.0003550143,0.0003165163,0.0003738696,0.001254324,0.001115151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004617497,"about_ca_system_score_gemma":0.000320531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115095,"about_ca_topic_score_gemma":0.001784171,"domain_scores_codex":[0.9997813,0.00002569301,0.00001390721,0.00005371757,0.00006676881,0.00005863581],"domain_scores_gemma":[0.999877,0.00002062235,0.00002705256,0.00001397316,0.00001963802,0.00004163582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004213334,0.000006360588,0.0001393467,0.000004688515,0.000001186357,0.00001480606,0.000009370642,0.00001828238,0.9992999,0.0001589286,0.00003532806,0.0002696],"study_design_scores_gemma":[0.00002822864,0.0001816521,0.0186452,0.000009615768,0.00001485283,0.0006349604,0.0001717825,0.0025883,0.9738685,0.0003569036,0.003487472,0.00001254798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896747,0.0006074645,0.006141754,0.0003377903,0.00005625438,0.00001959979,0.0006012428,0.0001629844,0.002398203],"genre_scores_gemma":[0.9915009,0.0002954713,0.003945101,0.0001713521,0.00001636153,0.00001261652,0.0007914656,0.00009527169,0.003171544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157028,"threshold_uncertainty_score":0.007215977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1185122706723852,"score_gpt":0.3647208592312473,"score_spread":0.2462085885588621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}