{"id":"W3030875985","doi":"10.1017/cjn.2019.124","title":"P.024 Long-term use of patisiran in patients with hereditary transthyretin amyloidosis (hATTR): 12 month efficacy & safety data from a global open label extension (OLE) study","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Amyloidosis; Tolerability; Transthyretin; Internal medicine; Placebo; Adverse effect; Quality of life (healthcare); Interim analysis; Population; Clinical trial; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007830566,0.0002588977,0.000421958,0.0001143406,0.0001786402,0.0005532061,0.000248962,0.0004276697,0.01162635],"category_scores_gemma":[0.000649441,0.00009208087,0.0006256442,0.0002230711,0.0002772052,0.0003798773,0.0001797369,0.0008816796,0.001645523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516757,"about_ca_system_score_gemma":0.0004040801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001873556,"about_ca_topic_score_gemma":0.0003954048,"domain_scores_codex":[0.9998239,0.00008273114,0.00001336942,0.0000237397,0.00003472026,0.00002170336],"domain_scores_gemma":[0.9993786,0.0002053366,0.0001813071,0.00003455317,0.00006760616,0.0001327056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4227554,0.007687072,0.09682038,0.002386939,0.00373836,0.001350676,0.0002734239,0.0009052079,0.02736099,0.0009649502,0.04679078,0.3889658],"study_design_scores_gemma":[0.2518854,0.2566788,0.3924721,0.0005938488,0.003678268,0.003052986,0.0003404354,0.003177149,0.009178457,0.001753204,0.07711619,0.00007309848],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551651,0.01053633,0.0008141131,0.002672683,0.0004559915,0.0007013881,0.004687114,0.0001980222,0.02476919],"genre_scores_gemma":[0.9870505,0.001787757,0.0007658771,0.001190997,0.0003470605,0.0004383797,0.002252733,0.00002290696,0.006143637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01162635,"threshold_uncertainty_score":0.03889406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06253106554009029,"score_gpt":0.3055473969201957,"score_spread":0.2430163313801054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}