{"id":"W3030986286","doi":"10.3851/imp3361","title":"Antiviral Activity of PLK1-Targeting siRNA Delivered by Lipid Nanoparticles in HBV-Infected Hepatocytes","year":2019,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"Agence Nationale de la Recherche","keywords":"cccDNA; Virology; HBsAg; Hepatitis B virus; PLK1; Viability assay; Small interfering RNA; Biology; Molecular biology; Chemistry; Cell; Cell culture; Transfection; Cell cycle; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003380221,0.0002860213,0.0007568201,0.0001289951,0.00006391833,0.0000169181,0.0001241581,0.0001253825,0.0001377065],"category_scores_gemma":[0.0001186959,0.0002465911,0.0001560457,0.0004009571,0.0001459874,0.0003063312,0.0000691466,0.0002555738,0.0001093226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007445515,"about_ca_system_score_gemma":0.00007019522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001866885,"about_ca_topic_score_gemma":0.0002013888,"domain_scores_codex":[0.998132,0.0001985133,0.0004248442,0.0003986599,0.0003390193,0.0005069883],"domain_scores_gemma":[0.9991298,0.0001983232,0.0001969484,0.0003036356,0.0001187158,0.00005261001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003783839,0.0002808785,0.4860711,0.00002981713,0.00006001314,0.000008208355,0.0003310807,3.865033e-7,0.501703,0.00001725573,0.0002732051,0.01084658],"study_design_scores_gemma":[0.00262419,0.0006529355,0.344927,0.0001235115,0.00001240166,0.000001306266,0.00004098851,0.0003516692,0.6500737,0.00002231269,0.000972642,0.0001973646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963879,0.0009959847,0.000008289519,0.0001950784,0.0001611933,0.0007306591,0.0000282334,0.00009545303,0.001397225],"genre_scores_gemma":[0.9972255,0.002080006,0.0001609456,0.0001730152,0.00007382639,0.00001925171,0.00001710685,0.00004477379,0.0002055852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1483707,"threshold_uncertainty_score":0.9999986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815977799059037,"score_gpt":0.2744658199071646,"score_spread":0.2563060419165742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}