{"id":"W3031124151","doi":"10.1200/jco.2020.38.15_suppl.3016","title":"Pharmacodynamic, safety, and efficacy results of a phase I/II trial of intratumoral INT230-6 alone (IT-01) or in combination with pembrolizumab (PEM) (Keynote A10) in patients with advanced solid tumors.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Nausea; Pembrolizumab; Toxicity; Dosing; Internal medicine; Cancer; Urology; Gastroenterology; Nuclear medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001427306,0.001328949,0.001297485,0.0003451263,0.000317062,0.0008963998,0.0006352866,0.001169977,0.002871472],"category_scores_gemma":[0.001071002,0.0005686025,0.000975389,0.000385976,0.0008879458,0.0008072466,0.0002324309,0.002841901,0.0007869593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009484302,"about_ca_system_score_gemma":0.0008375164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007341383,"about_ca_topic_score_gemma":0.001345835,"domain_scores_codex":[0.9995432,0.0002082924,0.00002611351,0.00008580845,0.00004035038,0.00009619875],"domain_scores_gemma":[0.9990636,0.0001903186,0.0001719585,0.00005859316,0.00004160119,0.0004740509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.769098,0.07779798,0.008237061,0.0004845732,0.0009452184,0.0004362716,0.0003388056,0.003182644,0.07065038,0.0001767761,0.003058371,0.06559382],"study_design_scores_gemma":[0.2958346,0.6718581,0.01977174,0.0000237583,0.0005900181,0.0005199731,0.00006176026,0.001682686,0.00755587,0.000156697,0.00190883,0.00003603214],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963884,0.0009580263,0.00022621,0.0001958065,0.000035304,0.0005682067,0.0005477633,0.00003401803,0.001046366],"genre_scores_gemma":[0.995317,0.0006500027,0.0004480805,0.0002729045,0.0000870814,0.0006521051,0.001416987,0.00001825323,0.001137629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002871472,"threshold_uncertainty_score":0.009606063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07339698169917563,"score_gpt":0.4612205001343791,"score_spread":0.3878235184352035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}