{"id":"W3031226324","doi":"10.1101/2020.05.30.124057","title":"Epigenome dysregulation resulting from NSD1 mutation in head and neck squamous cell carcinoma","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; Government of Canada; Genome Canada","keywords":"Epigenome; Epigenetics; Biology; Carcinogenesis; Epigenomics; Chromatin; Genetics; DNA methylation; Histone; Gene; Histone methyltransferase; Methyltransferase; Transcriptome; Mutation; EZH2; Methylation; Cancer research; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007423874,0.0001432679,0.0001615945,0.0003900933,0.0001165275,0.0001677615,0.00009767684,0.0001568458,0.001487493],"category_scores_gemma":[0.00008992133,0.00008399844,0.0001552672,0.0002023427,0.0001324422,0.00007082571,0.0001979238,0.0001665444,0.0001896774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995635,"about_ca_system_score_gemma":0.0001323262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001460281,"about_ca_topic_score_gemma":0.001398331,"domain_scores_codex":[0.999944,0.000005956096,0.000004299501,0.00001356626,0.00002188464,0.00001029169],"domain_scores_gemma":[0.9999582,0.000008069009,0.00001142793,0.000006455299,0.000005980542,0.000009895431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001760226,0.00001136905,0.007937499,0.00002802753,0.00001428326,0.0005037936,0.00002000742,0.0002002217,0.9876066,0.00009081075,0.0001140881,0.003297313],"study_design_scores_gemma":[0.00001317227,0.0000992742,0.1949533,0.000004344799,0.00004065584,0.002579107,0.00008641303,0.002093071,0.7974321,0.0002141331,0.002477332,0.000007035389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960316,0.0006045968,0.001368188,0.00006005758,0.00001355323,0.0000141668,0.0009174711,0.00006964264,0.0009206489],"genre_scores_gemma":[0.9975984,0.0003012724,0.0006905078,0.00003164387,0.000002606519,0.00001112015,0.0005151441,0.00000951015,0.0008398376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487493,"threshold_uncertainty_score":0.004976153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436509698482534,"score_gpt":0.226326450443179,"score_spread":0.2119613534583536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}