{"id":"W3031281461","doi":"10.1038/s41598-020-65579-9","title":"The RNA disruption assay is superior to conventional drug sensitivity assays in detecting cytotoxic drugs","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Health Sciences North; University of Sudbury; Laurentian University","funders":"","keywords":"Clonogenic assay; Cytotoxic T cell; Trypan blue; Viability assay; Cytotoxicity; Drug; Biology; Drug resistance; Cell growth; Cell; Pharmacology; In vitro; Biochemistry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002726672,0.001403944,0.001205206,0.002192495,0.0005104881,0.001562746,0.0008109381,0.001405348,0.002101676],"category_scores_gemma":[0.005151166,0.0006123716,0.0007765075,0.001373935,0.001042178,0.001256425,0.0009205601,0.001464728,0.001612003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005935995,"about_ca_system_score_gemma":0.0005915869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007193503,"about_ca_topic_score_gemma":0.001516374,"domain_scores_codex":[0.9930345,0.001881622,0.0006334395,0.00167563,0.002533946,0.0002408756],"domain_scores_gemma":[0.9919549,0.003934893,0.001839735,0.0007296992,0.001260348,0.0002805211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007647417,0.00003908944,0.0008356504,0.000198091,0.00001915362,0.00003953042,0.0000628609,0.0001402288,0.9906986,0.0002127845,0.0001136966,0.007563701],"study_design_scores_gemma":[0.000008368616,0.000518546,0.005643876,0.00002807707,0.00006893852,0.0004604638,0.00004218204,0.001463006,0.9865859,0.0001620246,0.004972865,0.00004588662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4745443,0.03604482,0.4633728,0.001139706,0.0008027341,0.0009039568,0.00256846,0.00321195,0.01741121],"genre_scores_gemma":[0.6971105,0.01346537,0.2705483,0.0007335236,0.0004083868,0.0008767156,0.002962876,0.0004410018,0.0134533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002726672,"threshold_uncertainty_score":0.01442021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102725971776672,"score_gpt":0.2660562415767437,"score_spread":0.2557836443990765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}