{"id":"W3031283578","doi":"10.1038/s41467-020-16517-w","title":"A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; European Commission; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Institut Universitaire de France; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Virology; Biology; Hepatitis B virus; Host factor; Permissive; Disease; Enhancer; Genome; Downregulation and upregulation; Transcription factor; Virus; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052439,0.0001510448,0.0003260241,0.0001043953,0.0002570685,0.00001979986,0.0005223547,0.0002103484,0.0001630083],"category_scores_gemma":[0.001802248,0.0001413976,0.0001312139,0.0004781114,0.0002053626,0.0001083367,0.0004584819,0.0009228718,0.0002466066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006233634,"about_ca_system_score_gemma":0.0001198415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003889726,"about_ca_topic_score_gemma":0.001865975,"domain_scores_codex":[0.9988987,0.0001061285,0.0003321162,0.0002029807,0.0002881454,0.0001719143],"domain_scores_gemma":[0.9976311,0.0003709465,0.0001465111,0.001315929,0.000398993,0.0001364857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004375127,0.0006582389,0.8192974,0.0003304916,0.00143087,0.00001952255,0.01403649,0.000004253959,0.1186861,0.009709129,0.03292533,0.0024647],"study_design_scores_gemma":[0.0004781958,0.0001966548,0.8243252,0.00007237913,0.0001772433,0.000004338568,0.0002828052,0.00006373908,0.001791118,0.00008167099,0.1723848,0.0001418574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8084221,0.04972123,0.0006734372,0.09515925,0.0003410077,0.001860532,0.0004095479,0.0005349099,0.042878],"genre_scores_gemma":[0.9909527,0.00221059,0.001749813,0.004316973,0.00009589462,0.00004476613,0.0001885341,0.00002782748,0.0004128428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1825307,"threshold_uncertainty_score":0.5766025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05196142965682651,"score_gpt":0.3269288211431337,"score_spread":0.2749673914863071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}