{"id":"W3031283578","doi":"10.1038/s41467-020-16517-w","title":"A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; European Commission; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Institut Universitaire de France; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Virology; Biology; Hepatitis B virus; Host factor; Permissive; Disease; Enhancer; Genome; Downregulation and upregulation; Transcription factor; Virus; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002453835,0.0004208552,0.0003586463,0.0004611827,0.000212226,0.0002816648,0.0002066986,0.0002586002,0.001589803],"category_scores_gemma":[0.0001966925,0.0001300747,0.000265024,0.0002798479,0.0001774547,0.00009411224,0.0001816959,0.0003034278,0.0002946977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002947334,"about_ca_system_score_gemma":0.0003811852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001425257,"about_ca_topic_score_gemma":0.004173858,"domain_scores_codex":[0.9998713,0.00002072752,0.000009533319,0.00002686603,0.00004839946,0.00002320534],"domain_scores_gemma":[0.999858,0.00006674216,0.00001784806,0.00001400494,0.00001180707,0.00003157003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977012,0.00005873846,0.001014333,0.00004479258,0.00001825316,0.0001420199,0.000005262026,0.0001724463,0.9957886,0.00006219742,0.0001011632,0.002394485],"study_design_scores_gemma":[0.00006258232,0.0007541799,0.01433697,0.000008211057,0.0000951718,0.0008700709,0.00002324946,0.002187412,0.9774789,0.00007140503,0.004100183,0.00001170556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869638,0.002790147,0.004491811,0.0002444541,0.00004068469,0.0001119978,0.002680743,0.0001947084,0.002481646],"genre_scores_gemma":[0.987816,0.001844561,0.005227452,0.0001272003,0.00001082755,0.00004540987,0.00287685,0.00003625,0.002015428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001589803,"threshold_uncertainty_score":0.005318403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05196142965682651,"score_gpt":0.3269288211431337,"score_spread":0.2749673914863071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}