{"id":"W3031292296","doi":"10.1200/jco.2020.38.15_suppl.3064","title":"Results of a first-in-human phase I study of SRF231, a fully human, high-affinity anti-CD47 antibody.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Dosing; Neutropenia; Pharmacodynamics; Pharmacokinetics; Adverse effect; Internal medicine; Cmax; Antibody; Anemia; Oncology; Leukopenia; Pharmacology; Gastroenterology; Toxicity; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003465424,0.0001922454,0.002435472,0.0002022086,0.00008633321,0.000004665165,0.000496097,0.000565813,0.0001518198],"category_scores_gemma":[0.003352627,0.0001529146,0.0004349866,0.0002817533,0.0003641762,0.000159578,0.0001574591,0.001063701,0.00001078958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004507384,"about_ca_system_score_gemma":0.0003112603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002235025,"about_ca_topic_score_gemma":0.0001833014,"domain_scores_codex":[0.9926568,0.001473389,0.005186286,0.0002839092,0.0001265141,0.0002731257],"domain_scores_gemma":[0.9926953,0.001751332,0.004708025,0.000291528,0.0004690671,0.00008477739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02154663,0.05110332,0.1193811,0.0001204374,0.001796618,0.000272005,0.003523009,0.0002600101,0.780608,0.0004021472,0.006748707,0.0142381],"study_design_scores_gemma":[0.09748911,0.101392,0.7567973,0.0001664982,0.0004725644,0.0000498748,0.001110178,0.00002709298,0.02395593,0.0001991356,0.0180793,0.0002610387],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962289,0.0004177994,0.00002590452,0.001496306,0.001149499,0.0002829256,0.00002415925,0.000008551528,0.0003659071],"genre_scores_gemma":[0.9993557,0.0001407208,0.0000733854,0.000134522,0.0002168818,0.000001821099,0.00002558398,0.00001350936,0.000037876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7566521,"threshold_uncertainty_score":0.6235677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1373446329578081,"score_gpt":0.4665843386607119,"score_spread":0.3292397057029038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}