{"id":"W3031364957","doi":"10.1038/s41598-020-65636-3","title":"Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Sherbrooke; McGill University Health Centre; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Phenotype; Signalling; Signal transduction; Profiling (computer programming); Signalling pathways; Cell biology; Biology; Computational biology; Genetics; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000315283,0.0003019868,0.0003176038,0.0002830267,0.0001593781,0.000595154,0.0002414807,0.0004134901,0.001278591],"category_scores_gemma":[0.0002340204,0.0001563108,0.0002823112,0.0001692081,0.0002934464,0.0002687566,0.0002447141,0.0007762286,0.0004448856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248683,"about_ca_system_score_gemma":0.00009995043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002547209,"about_ca_topic_score_gemma":0.0004557276,"domain_scores_codex":[0.9997862,0.00003079721,0.00001468599,0.00004420129,0.00007719818,0.00004694173],"domain_scores_gemma":[0.9998662,0.00004168865,0.00003958993,0.0000150907,0.00001941668,0.00001797451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001734557,0.000003117822,0.00007310752,0.000007733399,0.000001300956,0.000007963042,0.000004437717,0.0000341332,0.9995579,0.00001759138,0.000007599634,0.0002676604],"study_design_scores_gemma":[0.000003796851,0.00008782888,0.003552503,0.000003058503,0.000007296288,0.000129159,0.00003394884,0.001185881,0.9943315,0.00005048588,0.0006086979,0.000005830926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830869,0.0007145028,0.01423182,0.0001719633,0.00002809508,0.00002249923,0.0005389731,0.0001356186,0.001069589],"genre_scores_gemma":[0.9840282,0.0008392379,0.01184248,0.0001714088,0.000008422662,0.00004227798,0.0006051775,0.00005161947,0.002411213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001278591,"threshold_uncertainty_score":0.004277289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907589793579284,"score_gpt":0.2262717290367175,"score_spread":0.2071958311009247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}