{"id":"W3031402932","doi":"10.1200/jco.2020.38.15_suppl.5525","title":"<i>HSD3B1</i> (1245A&gt;C) polymorphism and clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate (AA) and enzalutamide (ENZA): Results from two prospective studies.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Kelowna General Hospital; BC Cancer Agency","funders":"","keywords":"Enzalutamide; Medicine; Prostate cancer; Internal medicine; Genotype; Oncology; Abiraterone acetate; Cohort; Hazard ratio; Prospective cohort study; Proportional hazards model; Androgen receptor; Cancer; Androgen deprivation therapy; Genetics; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005228599,0.0003184862,0.0003389628,0.0004197389,0.0003669803,0.0004901278,0.0003091688,0.0003399043,0.001308522],"category_scores_gemma":[0.000930215,0.0002469485,0.000458326,0.0007998043,0.0003319308,0.0000950493,0.0002108859,0.0004006638,0.0001609726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005474634,"about_ca_system_score_gemma":0.0004970512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03568837,"about_ca_topic_score_gemma":0.03903855,"domain_scores_codex":[0.9996847,0.00008825744,0.00002938125,0.00008530969,0.00006668861,0.00004564449],"domain_scores_gemma":[0.9990637,0.000182179,0.0003743201,0.00008307525,0.00007778814,0.0002190556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001675784,0.00004653745,0.9957443,0.00002270335,0.0002899294,0.00005804934,0.00004791394,0.00005555565,0.0008234628,0.000008011806,0.00007685075,0.001150981],"study_design_scores_gemma":[0.0000620621,0.0001611151,0.9991222,0.000004997535,0.0001755965,0.0001294455,0.00002801192,0.00009103488,0.00009714375,0.000008429774,0.0001169204,0.000003024857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990972,0.0004088092,0.000036543,0.00001616311,0.000003175659,0.000006873668,0.00033539,0.00000192017,0.00009379349],"genre_scores_gemma":[0.9994019,0.00008821733,0.00004263752,0.0000105655,0.000003800831,0.000004431594,0.0003745829,0.000001036478,0.00007276054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03568837,"threshold_uncertainty_score":0.0709613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1576711227538795,"score_gpt":0.4754497192702772,"score_spread":0.3177785965163977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}