{"id":"W3031412128","doi":"10.1080/03009742.2020.1732458","title":"Impact of immunogenicity on efficacy and tolerability of tumour necrosis factor inhibitors: pooled analysis of biosimilar studies in rheumatoid arthritis","year":2020,"lang":"en","type":"article","venue":"Scandinavian Journal of Rheumatology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Medicine; Rheumatoid arthritis; Biosimilar; Etanercept; Internal medicine; Infliximab; Tolerability; Adalimumab; Immunogenicity; Rheumatology; Gastroenterology; Tumor necrosis factor alpha; Immunology; Antibody; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05090076,0.001840492,0.006017894,0.003369879,0.0002164832,0.002360488,0.0007077486,0.001025337,0.001206836],"category_scores_gemma":[0.04819994,0.000722142,0.01480835,0.003286488,0.0004565472,0.0009404939,0.001272607,0.0005668927,0.0001717043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004870442,"about_ca_system_score_gemma":0.0005340845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000669569,"about_ca_topic_score_gemma":0.0006943263,"domain_scores_codex":[0.9505543,0.03440663,0.007151085,0.003605231,0.003801932,0.0004809187],"domain_scores_gemma":[0.9412947,0.03657806,0.01351761,0.004386055,0.003750937,0.0004725831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.04557558,0.0001197212,0.1400196,0.008106943,0.7681944,0.0001628224,0.0001414054,0.002166236,0.002693914,0.0001159611,0.000622821,0.03208066],"study_design_scores_gemma":[0.005391555,0.006013825,0.2890671,0.001005519,0.6877109,0.0006559757,0.000152198,0.004036902,0.002865602,0.0005514926,0.002441755,0.0001071534],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6664627,0.3164538,0.009825005,0.0004199194,0.0003299419,0.0004956417,0.003872287,0.0001675821,0.001973053],"genre_scores_gemma":[0.9875531,0.008978448,0.001164031,0.0001755783,0.0002155441,0.0001711787,0.001556313,0.0000319985,0.0001537144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05090076,"threshold_uncertainty_score":0.2691922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04119759123436458,"score_gpt":0.3328873287808801,"score_spread":0.2916897375465155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}