{"id":"W3031446019","doi":"10.1200/jco.2020.38.15_suppl.3511","title":"CodeBreak 100: Phase I study of AMG 510, a novel KRAS<sup>G12C</sup> inhibitor, in patients (pts) with advanced solid tumors other than non-small cell lung cancer (NSCLC) and colorectal cancer (CRC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Amgen","keywords":"KRAS; Medicine; Colorectal cancer; Cancer; Tolerability; Internal medicine; Response Evaluation Criteria in Solid Tumors; Clinical endpoint; Lung cancer; Oncology; Phases of clinical research; Gastroenterology; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00067604,0.001319348,0.001108108,0.0004589759,0.0002841991,0.0009050101,0.0008006834,0.001241611,0.008021042],"category_scores_gemma":[0.0005455075,0.000558735,0.0006825855,0.0004708931,0.0007661978,0.0008491995,0.0004603952,0.002861165,0.001809812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009325338,"about_ca_system_score_gemma":0.001308785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332378,"about_ca_topic_score_gemma":0.004610708,"domain_scores_codex":[0.999798,0.00006537092,0.000009959508,0.00004347778,0.00002980338,0.00005334055],"domain_scores_gemma":[0.9995484,0.00006513122,0.00007990759,0.00002706346,0.00002801414,0.0002513909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4948813,0.07900479,0.01299377,0.002607937,0.001198226,0.0007908421,0.0005331853,0.007773104,0.1501381,0.001375171,0.02242403,0.2262794],"study_design_scores_gemma":[0.4677294,0.4876177,0.01977319,0.00009873037,0.0003887313,0.0008837976,0.00007185096,0.00329493,0.009964547,0.0003487331,0.009763882,0.00006452483],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791808,0.001865839,0.001463312,0.0006168816,0.0001792093,0.003906948,0.004280344,0.00046402,0.008042634],"genre_scores_gemma":[0.9734074,0.002330118,0.002272331,0.001509249,0.0001615417,0.002574083,0.009365813,0.00009632674,0.00828313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008021042,"threshold_uncertainty_score":0.026833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04131832107028971,"score_gpt":0.4393586368519075,"score_spread":0.3980403157816178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}