{"id":"W3031455888","doi":"10.1200/jco.2020.38.15_suppl.6517","title":"Updated analysis of the inducible T-cell co-stimulatory receptor (ICOS) agonist, GSK3359609 (GSK609), combination with pembrolizumab (PE) in patients (pts) with anti-PD-1/L1 treatment-naïve head and neck squamous cell carcinoma (HNSCC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Pembrolizumab; Refractory (planetary science); Population; Gastroenterology; Cancer; Head and neck cancer; Combination therapy; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001860838,0.0004333288,0.001243737,0.0007696812,0.0001575073,0.001010291,0.0008477055,0.0005501647,0.003252208],"category_scores_gemma":[0.001883173,0.0003619865,0.001864396,0.001454287,0.0001447062,0.0005245238,0.0003189766,0.0006224269,0.0005295577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001106215,"about_ca_system_score_gemma":0.001343377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005552702,"about_ca_topic_score_gemma":0.01551749,"domain_scores_codex":[0.9993217,0.000171842,0.00009164012,0.0001199145,0.000230717,0.0000642091],"domain_scores_gemma":[0.998322,0.0003627983,0.0006777306,0.0001180228,0.0003092216,0.0002102884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1750531,0.001993428,0.3438516,0.006571704,0.01744854,0.00119247,0.0002975746,0.006113267,0.03987531,0.0008010392,0.04836507,0.3584368],"study_design_scores_gemma":[0.01814587,0.01913572,0.8800694,0.0006658153,0.02115816,0.003108962,0.0001464509,0.00286424,0.005936102,0.0004210689,0.04826345,0.00008475198],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8771475,0.03212357,0.001201175,0.001370581,0.0002248182,0.001450108,0.06934738,0.0002658141,0.01686898],"genre_scores_gemma":[0.9241335,0.007615979,0.002357627,0.001832464,0.0001988247,0.0004712039,0.0603025,0.00006305769,0.003024839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005552702,"threshold_uncertainty_score":0.01104081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05261490276482955,"score_gpt":0.3573437048378566,"score_spread":0.304728802073027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}