{"id":"W3031475478","doi":"10.1200/jco.2020.38.15_suppl.6505","title":"KEYNOTE-048: Progression after the next line of therapy following pembrolizumab (P) or P plus chemotherapy (P+C) vs EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Pembrolizumab; Internal medicine; Oncology; Population; Proportional hazards model; Progression-free survival; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001054976,0.0005715311,0.001048058,0.0003376137,0.000245285,0.0006592649,0.0007354649,0.0008335833,0.006159676],"category_scores_gemma":[0.0009604462,0.0002529715,0.0008685159,0.0003376464,0.0005102832,0.0009512677,0.0004775278,0.002367878,0.0005240618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007172101,"about_ca_system_score_gemma":0.0009511486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000411798,"about_ca_topic_score_gemma":0.001627533,"domain_scores_codex":[0.9996256,0.0001372329,0.00002682403,0.00008980688,0.00003585203,0.00008464856],"domain_scores_gemma":[0.9995126,0.0001157478,0.0001390103,0.00004266917,0.00001718937,0.0001728502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8072574,0.02437182,0.003874988,0.0010577,0.000914447,0.0001427522,0.0001257552,0.002774657,0.02325146,0.0007088367,0.002885842,0.1326344],"study_design_scores_gemma":[0.2906751,0.6763139,0.01556239,0.0001246278,0.001219638,0.0003617181,0.0000913544,0.002290578,0.00786223,0.000736281,0.004704785,0.00005734176],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934244,0.001318085,0.0003977302,0.0002281363,0.0001702307,0.000852211,0.0009827681,0.00005717642,0.002569417],"genre_scores_gemma":[0.9957733,0.0005670377,0.0007025797,0.0002499857,0.00006811714,0.0006735371,0.0005954965,0.000009794655,0.001360303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006159676,"threshold_uncertainty_score":0.0206061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.197878543197149,"score_gpt":0.4431868967722559,"score_spread":0.2453083535751068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}