{"id":"W3031510054","doi":"10.1093/nar/gkz697","title":"The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Canada Research Chairs; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Novartis Pharma; Canada Foundation for Innovation; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; AbbVie; Argonne National Laboratory; U.S. Department of Energy; Office of Science; Boehringer Ingelheim; European Molecular Biology Organization; Pfizer","keywords":"Biology; Protein subunit; Methyltransferase; Genetics; Computational biology; Protein–protein interaction; Protein structure; Nuclear magnetic resonance spectroscopy; Gene; Methylation; Biochemistry; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004961626,0.0001287836,0.0001263836,0.00008386993,0.0003903325,0.00009469499,0.0003329634,0.000119072,0.0003739303],"category_scores_gemma":[0.0001599759,0.0001071595,0.00009378797,0.0002983149,0.0002111866,0.00001647008,0.0001872952,0.0002973734,0.0005675537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716433,"about_ca_system_score_gemma":0.0002443213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001176358,"about_ca_topic_score_gemma":0.0001409515,"domain_scores_codex":[0.9983763,0.0001478306,0.0002702042,0.0003188611,0.0004723354,0.000414498],"domain_scores_gemma":[0.9987713,0.0001630131,0.00007458002,0.0005726543,0.0003272165,0.00009125761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003047216,0.0000501179,0.0006268785,0.00001600986,0.00007918023,1.232218e-7,0.0001546481,0.0000962551,0.924316,0.00004899281,0.06369329,0.01061371],"study_design_scores_gemma":[0.001977591,0.00031157,0.005148293,0.00001848046,0.00001188435,0.00002072829,0.001037227,0.0665334,0.08077295,0.0001119919,0.8438062,0.0002496749],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893827,0.0006023281,0.0005375547,0.001585209,0.0002168648,0.000759278,0.00009737183,0.00002200416,0.006796652],"genre_scores_gemma":[0.9847228,0.0001877473,0.0001278476,0.00006244676,0.00006000316,0.00005898218,0.0006206959,0.00002854127,0.01413096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8435431,"threshold_uncertainty_score":0.7294943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02632358370751854,"score_gpt":0.339508001416328,"score_spread":0.3131844177088094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}