{"id":"W3031510054","doi":"10.1093/nar/gkz697","title":"The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Canada Research Chairs; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Novartis Pharma; Canada Foundation for Innovation; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; AbbVie; Argonne National Laboratory; U.S. Department of Energy; Office of Science; Boehringer Ingelheim; European Molecular Biology Organization; Pfizer","keywords":"Biology; Protein subunit; Methyltransferase; Genetics; Computational biology; Protein–protein interaction; Protein structure; Nuclear magnetic resonance spectroscopy; Gene; Methylation; Biochemistry; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639725,0.0003272035,0.0004263306,0.0001659133,0.0005473582,0.0005865884,0.0006346421,0.0003704948,0.001303396],"category_scores_gemma":[0.0002092,0.0003371679,0.0003115533,0.0001676145,0.0005425626,0.0006990113,0.0003162819,0.0004637312,0.0002361505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005184952,"about_ca_system_score_gemma":0.0004204249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001884796,"about_ca_topic_score_gemma":0.001502746,"domain_scores_codex":[0.9999064,0.00001534529,0.000003842588,0.00003314744,0.00002260255,0.00001860837],"domain_scores_gemma":[0.9999375,0.00001204028,0.0000145935,0.000008508493,0.000007512364,0.00001991538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003477012,0.0002317883,0.00607577,0.0001575323,0.0002059507,0.0006328873,0.0002364582,0.5846585,0.3719648,0.02281076,0.0007642575,0.01191353],"study_design_scores_gemma":[0.00004835328,0.0001250783,0.002343682,0.000006471856,0.00003306511,0.00009796355,0.00005816394,0.9688359,0.02226037,0.004341307,0.001825179,0.00002444173],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940067,0.0002899135,0.05525311,0.0001764664,0.00001931892,0.00003810654,0.0001340009,0.0001774543,0.003844769],"genre_scores_gemma":[0.9916039,0.0002321787,0.006532438,0.00004734623,0.000007851644,0.00006351252,0.0001868393,0.0000345585,0.001291393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884796,"threshold_uncertainty_score":0.004360318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02632358370751854,"score_gpt":0.339508001416328,"score_spread":0.3131844177088094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}