{"id":"W3031568341","doi":"10.1021/acsnano.0c02240","title":"Suppressing Subcapsular Sinus Macrophages Enhances Transport of Nanovaccines to Lymph Node Follicles for Robust Humoral Immunity","year":2020,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Lymph node; Immune system; Antibody; Antigen; Humoral immunity; Lymph; Immunity; Immunology; Biology; Cell biology; Chemistry; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002611654,0.0002839552,0.0005776881,0.0001091185,0.0003167042,0.00001844089,0.000532008,0.0002199272,0.0002490407],"category_scores_gemma":[0.0001428551,0.0002518846,0.0002224823,0.0003095442,0.0001423138,0.0001725031,0.00006428124,0.0001321079,0.00005525015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002082857,"about_ca_system_score_gemma":0.0001148875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002064282,"about_ca_topic_score_gemma":0.000007048756,"domain_scores_codex":[0.9984155,0.0001917442,0.0005390511,0.0003339102,0.000052049,0.0004677022],"domain_scores_gemma":[0.9990669,0.0002156774,0.0001799812,0.000360525,0.0001453284,0.00003151885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002907323,0.0001302613,0.001100855,0.00009679591,0.0002472393,0.000005919633,0.002331777,0.00004805161,0.9880414,0.00005889717,0.0005183907,0.004513112],"study_design_scores_gemma":[0.002235833,0.0004065219,0.008015711,0.00008165205,0.00006872767,0.00002566663,0.0006127225,0.000002847607,0.9759454,0.00002105404,0.01230299,0.000280862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837626,0.01247215,0.001611462,0.001009103,0.0004199522,0.0004176434,0.0001414915,0.00008780799,0.00007782516],"genre_scores_gemma":[0.9966822,0.0001966495,0.001205273,0.0006806992,0.00004367936,0.00004773704,0.0001242781,0.00004337774,0.0009761644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01291958,"threshold_uncertainty_score":0.9999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02347299545208487,"score_gpt":0.2537103363479589,"score_spread":0.230237340895874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}