{"id":"W3031593708","doi":"10.1101/2020.05.31.20061010","title":"Lack of evidence for genetic association of saposins A, B, C and D with Parkinson disease","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; U.S. Department of Health and Human Services; National Institutes of Health; Canada First Research Excellence Fund; Parkinson Canada; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; McGill University; Parkinson's Foundation; Brookdale Foundation; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Genetic association; Disease; Genome-wide association study; Genetics; Gene; Locus (genetics); Biology; Genotype; Medicine; Internal medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001198431,0.0004187869,0.0005196547,0.001126884,0.0003832204,0.0005967344,0.0004283021,0.0008523047,0.006274024],"category_scores_gemma":[0.00464816,0.0002076517,0.000686541,0.000874959,0.0005839574,0.0003100895,0.0004247254,0.0004192339,0.0005232213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001464131,"about_ca_system_score_gemma":0.0002655878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400033,"about_ca_topic_score_gemma":0.0009469706,"domain_scores_codex":[0.9987499,0.0003102425,0.0001776996,0.0004374975,0.0002230847,0.0001014627],"domain_scores_gemma":[0.996316,0.00195994,0.0006140539,0.0003734964,0.0002657529,0.0004707717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00212534,0.00008041859,0.9727443,0.0001140555,0.001071737,0.001619885,0.0001922105,0.0001952238,0.01370184,0.0002721927,0.0006403567,0.007242552],"study_design_scores_gemma":[0.0001028906,0.0003138363,0.9909129,0.00003525782,0.0004590786,0.00409325,0.0001800946,0.0006843025,0.001420012,0.0004613636,0.001323484,0.0000133971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965562,0.0005778742,0.0005300844,0.0001973696,0.00003508538,0.000005047292,0.0005856171,0.00002336318,0.001489436],"genre_scores_gemma":[0.9987746,0.0001385092,0.0002362486,0.00006601093,0.00003302433,0.000003454904,0.0004195556,0.00001030743,0.0003183718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006274024,"threshold_uncertainty_score":0.02098864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1806755638818288,"score_gpt":0.3917968515223993,"score_spread":0.2111212876405706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}