{"id":"W3031646075","doi":"10.1200/jco.2020.38.15_suppl.502","title":"Biomarker data from KATHERINE: A phase III study of adjuvant trastuzumab emtansine (T-DM1) versus trastuzumab (H) in patients with residual invasive disease after neoadjuvant therapy for HER2-positive breast cancer.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Roche","keywords":"Medicine; Breast cancer; Oncology; Trastuzumab; Internal medicine; Neoadjuvant therapy; Adjuvant; Population; Biomarker; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005163921,0.0006211633,0.001455809,0.0002785653,0.0002442701,0.0008278697,0.0007782525,0.000979061,0.002985409],"category_scores_gemma":[0.00291876,0.0003379854,0.001290487,0.0004701701,0.000429235,0.0005465434,0.0003752849,0.001219098,0.0005831687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007594628,"about_ca_system_score_gemma":0.001118027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086395,"about_ca_topic_score_gemma":0.003221111,"domain_scores_codex":[0.99844,0.001067044,0.00007278289,0.0001658778,0.0001602502,0.00009405979],"domain_scores_gemma":[0.9980411,0.0006497217,0.0005179988,0.0001708257,0.0001199486,0.0005004607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8307871,0.007608919,0.0512931,0.001303151,0.01119633,0.0001647692,0.0002849047,0.001711501,0.02550933,0.0002497142,0.005981169,0.06391019],"study_design_scores_gemma":[0.5398721,0.2329215,0.1964848,0.0002124514,0.009116458,0.0006818463,0.0001530246,0.002006107,0.005243356,0.0003924685,0.01281527,0.0001006129],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986221,0.005198989,0.0005571265,0.0005316468,0.00006763603,0.001124078,0.004340483,0.00005313133,0.001905961],"genre_scores_gemma":[0.9798565,0.002271612,0.001963443,0.001173234,0.00008160363,0.00168682,0.01033981,0.00003995412,0.002586939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005163921,"threshold_uncertainty_score":0.02730978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09424698101711733,"score_gpt":0.4212322075352192,"score_spread":0.3269852265181019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}