{"id":"W3031718783","doi":"10.1200/jco.2020.38.15_suppl.e22504","title":"Bianca: Phase II, single-arm, global trial to determine efficacy and safety of tisagenlecleucel in pediatric/young adult (YA) patients (Pts) with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Novartis","keywords":"Medicine; Internal medicine; Lymphoma; Refractory (planetary science); Cytokine release syndrome; Gastroenterology; Surgery; Oncology; Immunotherapy; Chimeric antigen receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001505115,0.001251238,0.001053162,0.000494038,0.0002975931,0.001185358,0.0008739375,0.0009431119,0.006526793],"category_scores_gemma":[0.0007328839,0.000387256,0.0006836782,0.0004533747,0.0007294046,0.0009285318,0.0006876237,0.002373544,0.001652148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00117701,"about_ca_system_score_gemma":0.0012173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254284,"about_ca_topic_score_gemma":0.003499196,"domain_scores_codex":[0.9995919,0.0002407396,0.00001399746,0.00005451951,0.00004163303,0.0000573795],"domain_scores_gemma":[0.999535,0.00006397247,0.0001232285,0.00003419687,0.00003332302,0.0002103569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7750453,0.02110897,0.008115524,0.002632923,0.001764068,0.0003267646,0.0002694834,0.003223184,0.03430948,0.001470491,0.02026466,0.1314692],"study_design_scores_gemma":[0.7347842,0.2138138,0.02164559,0.0002074232,0.0009364942,0.001219261,0.0001210726,0.002837124,0.004092757,0.0006795023,0.01960106,0.0000617265],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966228,0.01328564,0.001077791,0.001675858,0.000241749,0.002308964,0.004953344,0.0005992443,0.009629475],"genre_scores_gemma":[0.9647024,0.00559094,0.00513263,0.002280131,0.0002029249,0.003194046,0.01085848,0.0001288013,0.007909678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006526793,"threshold_uncertainty_score":0.02183431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08639205978262311,"score_gpt":0.4210383654333999,"score_spread":0.3346463056507768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}