{"id":"W3031800029","doi":"10.1111/pcmr.12900","title":"Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ","year":2020,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institute of Genetics; Canadian Institutes of Health Research","keywords":"Heterotrimeric G protein; GNAQ; Biology; G protein-coupled receptor; Carcinogenesis; Cell biology; Gq alpha subunit; Melanocyte; G protein; Cancer research; Receptor; Melanoma; GTPase-activating protein; Signal transduction; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362369,0.0002501059,0.0001640143,0.0002486555,0.0001464624,0.0001984065,0.0001267237,0.0003184653,0.001558423],"category_scores_gemma":[0.00008339761,0.000166951,0.0002089273,0.0001127519,0.00021389,0.0001674843,0.0001936003,0.0006774754,0.0003443126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162647,"about_ca_system_score_gemma":0.0001179257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000475758,"about_ca_topic_score_gemma":0.0005534461,"domain_scores_codex":[0.9998553,0.00003528488,0.00001474426,0.00002572502,0.00003337954,0.00003556746],"domain_scores_gemma":[0.9998354,0.00003244501,0.00003769323,0.00001897921,0.000008212737,0.00006734049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006963513,0.00003905707,0.0001011523,0.000006368199,0.000001343414,0.00006536401,0.000007172937,0.00001431031,0.999498,0.00005814283,0.00001340287,0.0001260629],"study_design_scores_gemma":[0.00004519681,0.0006517011,0.005606082,0.000004553038,0.00001213845,0.0005360008,0.0000482444,0.001441461,0.9905324,0.00006647074,0.001051335,0.000004296365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984314,0.000221279,0.0005715195,0.00005928114,0.00001670989,0.00001227032,0.00007831793,0.00003537861,0.0005737635],"genre_scores_gemma":[0.9974359,0.000153068,0.0005270993,0.00003029263,0.000004480589,0.00001190963,0.0001044845,0.000009295344,0.001723463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558423,"threshold_uncertainty_score":0.005213439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06435489253828115,"score_gpt":0.3363518621175793,"score_spread":0.2719969695792981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}