{"id":"W3031836424","doi":"10.1073/pnas.2004317117","title":"A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Nucleosome; Core (optical fiber); DNA; Particle (ecology); Chemistry; Physics; Histone; Biochemistry; Biology; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008930924,0.0005208359,0.0002921205,0.0004231589,0.000501429,0.0003932643,0.0005836333,0.0008242704,0.001379353],"category_scores_gemma":[0.0005702551,0.0004054343,0.0003345952,0.00031506,0.0005562556,0.0004409823,0.0005032046,0.001862985,0.0005963478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003869446,"about_ca_system_score_gemma":0.0006916479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00071661,"about_ca_topic_score_gemma":0.002571287,"domain_scores_codex":[0.9997429,0.00009045369,0.00001537771,0.00004465884,0.00007653058,0.00003009741],"domain_scores_gemma":[0.9997116,0.00007179853,0.0000455729,0.00006743542,0.00005703043,0.00004658427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003994353,0.00001922138,0.00005949553,0.00006058231,0.000009921182,0.00005199066,0.00002438932,0.0001982118,0.9958271,0.0006860913,0.00008748214,0.002935491],"study_design_scores_gemma":[0.00005327167,0.0005796746,0.001115991,0.00002346901,0.00003392867,0.0008387051,0.00003222864,0.005090927,0.9793239,0.0007193988,0.01214441,0.00004411965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2688683,0.006182208,0.7150522,0.001746996,0.0003981218,0.0006660933,0.0006742558,0.000963776,0.005447965],"genre_scores_gemma":[0.2879018,0.005481005,0.6985738,0.0006842769,0.0001135013,0.0007417876,0.0007137312,0.0001315055,0.005658538],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001379353,"threshold_uncertainty_score":0.004723132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03874762500256402,"score_gpt":0.3025947036578465,"score_spread":0.2638470786552825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}