{"id":"W3031848108","doi":"10.1200/jco.2020.38.15_suppl.10501","title":"Randomized comparisons of bevacizumab (B) and irinotecan (I), added to temozolomide (T), in children with relapsed or refractory high-risk neuroblastoma (RR-HRNB): First survival results of the ITCC-SIOPEN BEACON-Neuroblastoma phase II trial.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Cancer Research UK","keywords":"Medicine; Bevacizumab; Internal medicine; Irinotecan; Hazard ratio; Refractory (planetary science); Progression-free survival; Oncology; Chemotherapy; Randomized controlled trial; Topotecan; Surgery; Gastroenterology; Confidence interval; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002687936,0.001396301,0.001909788,0.0004444422,0.0002317839,0.000892014,0.0009382197,0.001302691,0.005743394],"category_scores_gemma":[0.003176063,0.0006644932,0.001899411,0.0004113392,0.0008734888,0.0008569955,0.0005830531,0.002558991,0.0007558989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001331867,"about_ca_system_score_gemma":0.001171052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227728,"about_ca_topic_score_gemma":0.002918273,"domain_scores_codex":[0.9985383,0.001013491,0.00007525373,0.0001577704,0.00008748387,0.0001277301],"domain_scores_gemma":[0.9982961,0.0006090885,0.0005394709,0.00009378747,0.00006226792,0.0003993503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9860909,0.002900358,0.0003533663,0.0002923234,0.0007288875,0.00001862788,0.00002968517,0.0004030973,0.001013738,0.0001121494,0.0004542738,0.007602534],"study_design_scores_gemma":[0.9318163,0.06507713,0.0009490176,0.00004209038,0.0006469936,0.00002010608,0.00001538647,0.0003968409,0.0003104597,0.0001796463,0.0005355192,0.00001043059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857942,0.004815018,0.0008421468,0.0007501872,0.0005176173,0.003576551,0.001202469,0.00007911173,0.002422603],"genre_scores_gemma":[0.9841926,0.002385463,0.001966102,0.001078523,0.0002641644,0.005648673,0.001555466,0.00003735253,0.002871519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005743394,"threshold_uncertainty_score":0.01921356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09320385933477743,"score_gpt":0.4166054603129126,"score_spread":0.3234016009781352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}