{"id":"W3031857414","doi":"10.1186/s13223-020-00440-2","title":"Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps","year":2020,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beijing Nova Program; Beijing Municipal Administration of Hospitals; Beijing Technology and Business University; Beijing Advanced Innovation Center for Food Nutrition and Human Health; National Natural Science Foundation of China","keywords":"Mucin; Nasal polyps; Epidermal growth factor; Downregulation and upregulation; Mucus; LY294002; Medicine; Amphiregulin; Heparin-binding EGF-like growth factor; Mucin 2; Immunology; Internal medicine; Gene expression; Pathology; Biology; PI3K/AKT/mTOR pathway; Signal transduction; Receptor; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093543,0.0002214597,0.0001783094,0.0002054689,0.0001497466,0.0001937101,0.00006748462,0.0002267465,0.0008310387],"category_scores_gemma":[0.0001217639,0.0001081556,0.0002511715,0.0001439876,0.0001778145,0.000136811,0.0001515683,0.0003069794,0.0002210863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683157,"about_ca_system_score_gemma":0.000122487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005267172,"about_ca_topic_score_gemma":0.0006410439,"domain_scores_codex":[0.999927,0.00001207999,0.000008576526,0.00001291355,0.00002040303,0.00001904962],"domain_scores_gemma":[0.9999423,0.000007779669,0.00001956078,0.000005411366,0.000008211821,0.00001674747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003358501,0.00004530384,0.00302225,0.00009015031,0.00000710258,0.0003805626,0.00003220139,0.00001863242,0.9945983,0.000009886473,0.00002890374,0.001430788],"study_design_scores_gemma":[0.0001020563,0.003082601,0.3135082,0.00004040203,0.00008124128,0.005336375,0.0003763237,0.0008812937,0.672196,0.00005128096,0.004331123,0.0000131674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977132,0.001681028,0.0001618801,0.00002087972,0.00001129052,0.00001516072,0.00007134148,0.000009156581,0.0003160651],"genre_scores_gemma":[0.9976487,0.0009688117,0.0005033362,0.00002785173,0.00001025643,0.00002394009,0.0002173341,0.000002861443,0.0005968963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008310387,"threshold_uncertainty_score":0.00278008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121154758246307,"score_gpt":0.292410047322374,"score_spread":0.2711984997399109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}