{"id":"W3031916639","doi":"10.1200/jco.2020.38.15_suppl.7501","title":"Effect of enasidenib (ENA) plus azacitidine (AZA) on complete remission and overall response versus AZA monotherapy in mutant<i>-IDH2</i> (<i>mIDH2</i>) newly diagnosed acute myeloid leukemia (ND-AML).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Discontinuation; Internal medicine; Clinical endpoint; Gastroenterology; Azacitidine; Myeloid leukemia; Surrogate endpoint; Phases of clinical research; Surgery; Oncology; Chemotherapy; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009041438,0.0005918324,0.001352473,0.0003452009,0.0002158788,0.0006099438,0.0006099781,0.0006937694,0.002967186],"category_scores_gemma":[0.0008109837,0.000323323,0.0007082961,0.0002999201,0.0005918395,0.0007375969,0.000310803,0.002123326,0.0004500504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005679506,"about_ca_system_score_gemma":0.0007683024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007236056,"about_ca_topic_score_gemma":0.002675095,"domain_scores_codex":[0.9996397,0.0001813958,0.00002697476,0.00005407534,0.0000307223,0.00006708958],"domain_scores_gemma":[0.9993609,0.0001641082,0.0001213744,0.00003202729,0.00001931718,0.0003023313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8738043,0.02141485,0.001840659,0.0005459914,0.0007430605,0.0000877845,0.0001251534,0.001749701,0.03114012,0.0002581326,0.001245204,0.06704513],"study_design_scores_gemma":[0.2429132,0.730004,0.01392262,0.00006234081,0.001003782,0.0001631403,0.00007789392,0.001734411,0.007847884,0.0002725327,0.001961865,0.00003629482],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944259,0.002498394,0.00015134,0.0002200231,0.0001301527,0.0004011669,0.000386766,0.00003898697,0.001747252],"genre_scores_gemma":[0.996274,0.001278213,0.000359208,0.000189681,0.0001185475,0.000302507,0.0004305296,0.00000738734,0.001039864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002967186,"threshold_uncertainty_score":0.0099262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09172971033791527,"score_gpt":0.4350698053810392,"score_spread":0.343340095043124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}