{"id":"W3032001277","doi":"10.1200/jco.2020.38.15_suppl.5578","title":"Quality of life (QOL) for the treatment sequence of abiraterone acetate plus prednisone (AAP) followed by enzalutamide (ENZ) versus the opposite sequence for metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized clinical trial.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Kelowna General Hospital; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute","keywords":"Medicine; Enzalutamide; Abiraterone acetate; Prostate cancer; Quality of life (healthcare); Internal medicine; Randomized controlled trial; Prednisone; Sequence (biology); Abiraterone; Urology; Gastroenterology; Surgery; Oncology; Cancer; Androgen deprivation therapy; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002249602,0.001089978,0.001518316,0.0004282438,0.0003066343,0.0008072839,0.0005502785,0.001242316,0.004732709],"category_scores_gemma":[0.00205466,0.0004879224,0.001741188,0.0003837967,0.0008683802,0.0007013421,0.0004421544,0.002175925,0.0005557156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007531343,"about_ca_system_score_gemma":0.001060417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008118242,"about_ca_topic_score_gemma":0.001578874,"domain_scores_codex":[0.9989599,0.000653632,0.00007224948,0.0001264367,0.00009135028,0.00009641062],"domain_scores_gemma":[0.9987293,0.0003656214,0.0004264177,0.00007611296,0.00005191775,0.0003505834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.978647,0.006157265,0.000782082,0.0002907058,0.0005369693,0.00001358045,0.00002148281,0.000313629,0.0013624,0.00003781153,0.0001962523,0.01164074],"study_design_scores_gemma":[0.8500449,0.1448106,0.00344993,0.00003171309,0.0006087645,0.00002506495,0.00001154096,0.0003435123,0.0003308257,0.00008014491,0.0002528828,0.000009926412],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933302,0.00241067,0.0003369313,0.0003261738,0.0002126649,0.001888303,0.0005051225,0.00002979745,0.0009601255],"genre_scores_gemma":[0.992744,0.001253291,0.001064123,0.0004499483,0.0002382161,0.002673653,0.0005697937,0.000006916428,0.001000095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004732709,"threshold_uncertainty_score":0.01583242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5228100287158628,"score_gpt":0.5821295097350553,"score_spread":0.05931948101919249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}