{"id":"W3032063460","doi":"10.1186/s12915-020-00794-4","title":"Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease","year":2020,"lang":"en","type":"article","venue":"BMC Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Instituto de Salud Carlos III; Horizon 2020 Framework Programme; Generalitat de Catalunya; European Commission; Ministerio de Ciencia, Innovación y Universidades; Universitat de Barcelona; University of Calgary","keywords":"Huntington's disease; Neuroscience; Basal ganglia; Biology; Medium spiny neuron; Striatum; Excitatory postsynaptic potential; Premovement neuronal activity; Calcium imaging; Inhibitory postsynaptic potential; Disease; Central nervous system; Internal medicine; Dopamine; Medicine; Calcium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008240507,0.0001864738,0.0002889096,0.00007121994,0.00005865708,0.00001777048,0.0002020142,0.00009128555,0.0000415995],"category_scores_gemma":[0.001918751,0.0001854425,0.00003815139,0.0003462912,0.0002395088,0.00005448921,0.0002614753,0.0002403309,0.00001083694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001729825,"about_ca_system_score_gemma":0.00009664572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005523318,"about_ca_topic_score_gemma":0.0005423679,"domain_scores_codex":[0.9976071,0.000913157,0.0002155353,0.0007660681,0.00005837369,0.0004398176],"domain_scores_gemma":[0.9990492,0.0004834074,0.0001027921,0.0001525639,0.00001489168,0.0001971125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005341177,0.00009809552,0.8809465,0.00002279815,0.000001229149,0.00002653505,0.00003426699,0.001284529,0.1154639,0.001019712,0.00008274194,0.0004855458],"study_design_scores_gemma":[0.0009610371,0.0001527232,0.9665596,0.000007987524,0.000006206004,0.00000159731,0.00001669535,0.003261002,0.0283184,0.0004177598,0.0001117423,0.0001852559],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974064,0.00009440204,0.0001685139,0.00165901,0.0001933323,0.0002943543,0.0000727239,0.00003705856,0.00007420861],"genre_scores_gemma":[0.9977424,0.00002875021,0.00005243258,0.002009584,0.0001016983,0.00003122789,0.000009157227,0.00001505086,0.000009680658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08714549,"threshold_uncertainty_score":0.7562124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04323067302066191,"score_gpt":0.2772687438128478,"score_spread":0.2340380707921859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}