{"id":"W3032092952","doi":"10.3389/fimmu.2020.00980","title":"Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chinese Government Scholarship; Partenariat Canadien Contre Le Cancer; Deutschen Konsortium für Translationale Krebsforschung","keywords":"Metastasis; Cancer research; Gene knockdown; Colorectal cancer; Inflammation; Medicine; Cancer; Carcinogenesis; Tumor necrosis factor alpha; Tumor progression; Oncogene; Cytokine; Immunology; Biology; Internal medicine; Cell cycle; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142093,0.0001315633,0.0003915489,0.0001678457,0.00003124829,0.000005543499,0.00006050687,0.0001047781,0.00002243643],"category_scores_gemma":[0.00005744908,0.0001193367,0.00004295414,0.0002167976,0.0003496017,0.00008932076,0.00004773832,0.0002084013,7.403811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003846197,"about_ca_system_score_gemma":0.00006202621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007812996,"about_ca_topic_score_gemma":0.000004346834,"domain_scores_codex":[0.9991181,0.00006948487,0.0003024825,0.0002485781,0.00008241522,0.0001788692],"domain_scores_gemma":[0.999662,0.00001147811,0.0001225926,0.0001254006,0.0000322568,0.00004627461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008984111,0.0001320712,0.1121056,0.0007172999,0.001121944,0.00008478866,0.003612618,2.553313e-7,0.5970131,0.00009944286,0.001816959,0.2743118],"study_design_scores_gemma":[0.01708931,0.003991292,0.5839828,0.0003260812,0.0004466141,0.0006990894,0.003787585,0.0004542748,0.3674579,0.001236818,0.01987548,0.0006526803],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838285,0.01215836,0.000718353,0.002265043,0.000400337,0.0004672746,0.000006393434,0.00002988674,0.000125781],"genre_scores_gemma":[0.9931843,0.001227744,0.005117529,0.000336934,0.00004828618,0.00002803378,0.000008082551,0.00001898752,0.00003004798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4718772,"threshold_uncertainty_score":0.486641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170115508033678,"score_gpt":0.2291603234960419,"score_spread":0.2174591684157051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}