{"id":"W3032176512","doi":"10.1200/jco.2020.38.15_suppl.1055","title":"Updated results from the phase IIIb complement-1 study of ribociclib (RIB) plus letrozole (LET) in the treatment of HR+, HER2-advanced breast cancer (ABC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Neutropenia; Tolerability; Internal medicine; Population; Adverse effect; Phases of clinical research; Nausea; Febrile neutropenia; Gastroenterology; Surgery; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001436746,0.0002383017,0.002082102,0.00005928377,0.00005366675,0.000005714296,0.0004728649,0.0001452469,0.0002607531],"category_scores_gemma":[0.0005676479,0.000121321,0.0003936889,0.0003707895,0.0003711835,0.0001047739,0.00005473066,0.0007078483,0.000003099788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003518866,"about_ca_system_score_gemma":0.0009924287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008673712,"about_ca_topic_score_gemma":0.001176741,"domain_scores_codex":[0.9941666,0.00106293,0.003559469,0.0003021831,0.0006264001,0.0002823944],"domain_scores_gemma":[0.9926359,0.003165904,0.00310144,0.0004314091,0.0004532088,0.0002121412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2213669,0.03281355,0.06855508,0.00002934467,0.003120991,0.0008337593,0.02644971,0.002484066,0.002615073,0.00003669022,0.002675748,0.6390191],"study_design_scores_gemma":[0.272939,0.08731101,0.4426582,0.0002323867,0.001438064,0.0001176232,0.02527263,0.0004901163,0.0005314057,0.0001616358,0.1686202,0.0002277161],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488155,0.001071332,0.00006512568,0.04829369,0.0004027361,0.000852163,0.0003617176,0.000007947672,0.0001297903],"genre_scores_gemma":[0.9936399,0.0009103818,0.0006407808,0.003682219,0.001033515,0.00002331629,0.00002453164,0.00002296135,0.00002234853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6387914,"threshold_uncertainty_score":0.4947325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1977987316976941,"score_gpt":0.5158389428914423,"score_spread":0.3180402111937481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}