{"id":"W3032183412","doi":"10.1038/s42003-020-0997-y","title":"Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Fatty acid synthase; Acyl carrier protein; Steric effects; Chemistry; ATP synthase; Fatty acid; Enzyme; Internal medicine; Biochemistry; Medicine; Stereochemistry; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691201,0.0001131726,0.0002922783,0.0001049207,0.0000939485,0.000005705242,0.0003760607,0.0001075719,0.0001280013],"category_scores_gemma":[0.000428505,0.0000872227,0.00006707508,0.0003722823,0.000287634,0.00005995515,0.0004612957,0.0003366921,0.00001284982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004607963,"about_ca_system_score_gemma":0.00007059827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005417852,"about_ca_topic_score_gemma":0.00006798737,"domain_scores_codex":[0.998984,0.0002412818,0.0003630857,0.0002168707,0.00004337289,0.0001513509],"domain_scores_gemma":[0.9987568,0.00007956153,0.0001347836,0.0008468273,0.0001102932,0.00007167866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002406364,0.0001663003,0.002739987,0.00005094366,0.00002637113,0.000002493706,0.0004932412,2.188969e-7,0.9915304,0.0004797083,0.0001397394,0.004130013],"study_design_scores_gemma":[0.0008464238,0.0004396387,0.007468001,0.0002091963,0.00004832458,0.00005711878,0.0004434763,0.0003117626,0.9670264,0.0002879698,0.02268176,0.0001798929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603116,0.001102798,0.00006264704,0.0372045,0.00003898346,0.0007198558,0.00007587097,0.00003634943,0.0004474281],"genre_scores_gemma":[0.9886105,0.00009671637,0.01070206,0.0003543201,0.0000479959,0.00001140981,0.0001161346,0.00001017629,0.00005070076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03685018,"threshold_uncertainty_score":0.3556838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03681403692572539,"score_gpt":0.303439829472597,"score_spread":0.2666257925468716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}