{"id":"W3032231431","doi":"10.1186/s13063-020-04364-5","title":"Genetic basis for prediction of non-responders to dietary plant sterol intervention (GenePredict-PS): a study protocol for a double-blind, placebo-controlled, randomized two-period crossover study","year":2020,"lang":"en","type":"article","venue":"Trials","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Mitacs; University of Manitoba","keywords":"Medicine; Crossover study; Placebo; Single-nucleotide polymorphism; Randomized controlled trial; Clinical trial; Internal medicine; Biology; Genetics; Genotype; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0263337,0.005494947,0.007917851,0.002121836,0.003280488,0.001728718,0.003084705,0.007619717,0.02683905],"category_scores_gemma":[0.01943193,0.002654978,0.002895276,0.001955482,0.004202098,0.001922741,0.001773371,0.005005171,0.007567792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002189125,"about_ca_system_score_gemma":0.009043402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009305567,"about_ca_topic_score_gemma":0.001530271,"domain_scores_codex":[0.9820629,0.0104188,0.001609123,0.002214198,0.001853108,0.001841797],"domain_scores_gemma":[0.9879434,0.003028532,0.002610418,0.002262804,0.002169898,0.001984956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9219356,0.04977822,0.001321747,0.001914667,0.0005083832,0.0001643404,0.0002453407,0.001216341,0.004392819,0.001253933,0.003322698,0.01394584],"study_design_scores_gemma":[0.8450139,0.1374557,0.003671444,0.0003315058,0.0003379942,0.00005151504,0.00005606936,0.00161684,0.001125022,0.001087563,0.009163357,0.0000890934],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01965181,0.0001963924,0.003113549,0.0002328937,0.000390672,0.9746332,0.0008529261,0.0001339107,0.000794703],"genre_scores_gemma":[0.01162001,0.0001405963,0.004465781,0.0002259046,0.0001395446,0.9824974,0.0002048614,0.00001154777,0.0006944276],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02683905,"threshold_uncertainty_score":0.1392676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1846622689612855,"score_gpt":0.4380317664644756,"score_spread":0.2533694975031901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}