{"id":"W3032231431","doi":"10.1186/s13063-020-04364-5","title":"Genetic basis for prediction of non-responders to dietary plant sterol intervention (GenePredict-PS): a study protocol for a double-blind, placebo-controlled, randomized two-period crossover study","year":2020,"lang":"en","type":"article","venue":"Trials","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Mitacs; University of Manitoba","keywords":"Medicine; Crossover study; Placebo; Single-nucleotide polymorphism; Randomized controlled trial; Clinical trial; Internal medicine; Biology; Genetics; Genotype; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007320734,0.0004578184,0.003965956,0.0003215969,0.0001204064,0.00009200114,0.0002296755,0.0001327776,0.0001152661],"category_scores_gemma":[0.002321842,0.0003231615,0.001348357,0.0002662794,0.00005547774,0.0001301482,0.00009266032,0.000161876,0.000007870842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005354313,"about_ca_system_score_gemma":0.0001596491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007283655,"about_ca_topic_score_gemma":0.00004303536,"domain_scores_codex":[0.9939883,0.001117812,0.003054642,0.0007772513,0.0006563457,0.0004055941],"domain_scores_gemma":[0.9965887,0.001271934,0.0009764447,0.0004888395,0.0003265519,0.0003475514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9716408,0.003589071,0.001158946,0.0005124206,0.002783047,0.000006074671,0.009422927,0.000230354,0.006920578,0.000001315093,0.000919003,0.002815486],"study_design_scores_gemma":[0.9673471,0.01643493,0.00293881,0.000219692,0.00467805,0.000004537321,0.002526344,0.003122394,0.001361258,0.000008025728,0.001147792,0.0002110732],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4715847,0.00002302672,0.005873839,0.00026955,0.0003860394,0.5213466,0.0004365179,0.00006328626,0.00001645557],"genre_scores_gemma":[0.4666683,7.80078e-7,0.0005604008,0.0001954513,0.001196209,0.5311725,0.00003711674,0.00004864094,0.0001205472],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01284586,"threshold_uncertainty_score":0.999922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1846622689612855,"score_gpt":0.4380317664644756,"score_spread":0.2533694975031901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}