{"id":"W3032315201","doi":"10.1128/msystems.00283-20","title":"Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death","year":2020,"lang":"en","type":"article","venue":"mSystems","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Michael Smith Health Research BC; Canada Foundation for Innovation; Ministry of Technology, Innovation and Citizens' Services; Canada Research Chairs; Government of Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Mitochondrion; Biology; Stable isotope labeling by amino acids in cell culture; Effector; Proteolysis; Enteropathogenic Escherichia coli; Apoptosis; Cell biology; Proteomics; Programmed cell death; Quantitative proteomics; Mitochondrial DNA; Biochemistry; Virulence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005075186,0.0001556749,0.0002251858,0.00003196389,0.00008230375,0.00002761626,0.000105979,0.0001032503,0.000025338],"category_scores_gemma":[0.00001763913,0.0001413377,0.0001558404,0.0000928423,0.0000244931,0.000005387009,0.00009877847,0.00006871375,0.00001946865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005902637,"about_ca_system_score_gemma":0.00003482781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001961826,"about_ca_topic_score_gemma":0.0001094895,"domain_scores_codex":[0.9988925,0.0001342864,0.0002440223,0.000315176,0.0001738126,0.0002402317],"domain_scores_gemma":[0.9994585,0.000003689137,0.0001292455,0.0001996854,0.00007379323,0.0001350992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006718943,0.00006174266,0.05072244,0.0002085465,0.0001413113,0.000006585491,0.00007705185,0.00005729724,0.9479384,0.000003402535,0.00009481734,0.00001645169],"study_design_scores_gemma":[0.003079831,0.0006537026,0.006745248,0.00003791921,0.00004894202,0.000002464231,0.00001269048,0.00007389532,0.9879572,8.720926e-7,0.001241902,0.00014535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978317,0.0005116704,0.0003126045,0.00004196431,0.00009945001,0.0008611152,0.00005862469,0.00001636232,0.0002664928],"genre_scores_gemma":[0.998106,0.00002849281,0.00002668596,0.00002310474,0.0002407268,0.0002468085,0.00005906417,0.00002476688,0.001244363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04397719,"threshold_uncertainty_score":0.5763584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481785791511414,"score_gpt":0.2501150095670917,"score_spread":0.2252971516519775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}