{"id":"W3032315201","doi":"10.1128/msystems.00283-20","title":"Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death","year":2020,"lang":"en","type":"article","venue":"mSystems","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Michael Smith Health Research BC; Canada Foundation for Innovation; Ministry of Technology, Innovation and Citizens' Services; Canada Research Chairs; Government of Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Mitochondrion; Biology; Stable isotope labeling by amino acids in cell culture; Effector; Proteolysis; Enteropathogenic Escherichia coli; Apoptosis; Cell biology; Proteomics; Programmed cell death; Quantitative proteomics; Mitochondrial DNA; Biochemistry; Virulence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006084794,0.0005733315,0.0004318527,0.000559158,0.0005169437,0.001239935,0.0005172379,0.0007506465,0.02640315],"category_scores_gemma":[0.0006877777,0.0001961286,0.0003400273,0.0004476511,0.0007177496,0.0007803753,0.0007871805,0.0007040714,0.004856272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000828248,"about_ca_system_score_gemma":0.0005115004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000179077,"about_ca_topic_score_gemma":0.0003624216,"domain_scores_codex":[0.999647,0.00002975004,0.00002250496,0.000128548,0.000117079,0.00005516264],"domain_scores_gemma":[0.9994678,0.00009763745,0.000107633,0.00009711157,0.00006051865,0.0001694158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001908878,0.0001697995,0.004028091,0.001366722,0.00005391286,0.001218671,0.0004375193,0.0005255432,0.8181859,0.01112533,0.03908021,0.1218995],"study_design_scores_gemma":[0.0002231881,0.001436787,0.02819417,0.00027957,0.0001061099,0.003879837,0.0004238343,0.003720596,0.6515295,0.008506354,0.3016401,0.00005991904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6121704,0.04943255,0.04033644,0.03849798,0.01664878,0.0007740842,0.007611382,0.003279224,0.2312492],"genre_scores_gemma":[0.7779193,0.01485955,0.006384965,0.004667495,0.006745945,0.000184989,0.002620611,0.0003648855,0.1862523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02640315,"threshold_uncertainty_score":0.08832735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481785791511414,"score_gpt":0.2501150095670917,"score_spread":0.2252971516519775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}