{"id":"W3032359244","doi":"10.1200/jco.2020.38.15_suppl.3530","title":"Exploitation of treatment induced tumor lysis to enhance sensitivity of ctDNA analysis: A first-in-human pilot study.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; London Health Sciences Centre; Sunnybrook Health Science Centre; Western University; Cancer Care Ontario","funders":"","keywords":"Medicine; Lung cancer; Internal medicine; Chemotherapy; Oncology; Prospective cohort study; Cohort; Cancer; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00250217,0.001055544,0.0008121692,0.0003138982,0.0005194261,0.0008298458,0.0007039168,0.0009392594,0.004558629],"category_scores_gemma":[0.001169874,0.0005384912,0.0008691052,0.0002687505,0.001047153,0.0005927085,0.0004169251,0.001550865,0.001042325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006113936,"about_ca_system_score_gemma":0.001060901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009826752,"about_ca_topic_score_gemma":0.001261904,"domain_scores_codex":[0.9991308,0.0003815866,0.00002846072,0.0001904039,0.00009071769,0.0001780054],"domain_scores_gemma":[0.9990976,0.0002078828,0.0001293846,0.0001974315,0.00009030646,0.0002774442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1190092,0.1826684,0.02158982,0.000849737,0.0004911004,0.0008400384,0.001031105,0.001116238,0.6048427,0.0002853928,0.003484287,0.0637919],"study_design_scores_gemma":[0.008431963,0.8930215,0.03012283,0.00002230636,0.0002528433,0.001223098,0.0002092462,0.001191986,0.06126529,0.0001299226,0.004092209,0.00003686697],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947674,0.0004340187,0.001757123,0.0001080287,0.00005031792,0.001698171,0.0005133331,0.00007067073,0.0006010278],"genre_scores_gemma":[0.9902001,0.0005135025,0.003083725,0.000334805,0.00007034397,0.001646284,0.001734921,0.00004337442,0.002372816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004558629,"threshold_uncertainty_score":0.01525009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1069486422839924,"score_gpt":0.4421392580997591,"score_spread":0.3351906158157667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}