{"id":"W3032582312","doi":"10.3390/v12060586","title":"Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium","year":2020,"lang":"en","type":"article","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia; University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; Consejo Nacional de Ciencia y Tecnología; Public Health Agency; Public Health Agency of Canada","keywords":"HIV drug resistance; Sanger sequencing; Drug resistance; Human immunodeficiency virus (HIV); Medicine; DNA sequencing; Computational biology; Virology; Antiretroviral therapy; Biology; Viral load; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02812278,0.001438602,0.0007522187,0.001281555,0.005120752,0.007317914,0.002843168,0.00758732,0.009859348],"category_scores_gemma":[0.02497411,0.0007988263,0.001273319,0.0005239155,0.002957935,0.003764108,0.008582592,0.01229411,0.002597515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01539508,"about_ca_system_score_gemma":0.07724416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1012141,"about_ca_topic_score_gemma":0.1702723,"domain_scores_codex":[0.9885666,0.003838936,0.0005416987,0.001271247,0.003158682,0.002622848],"domain_scores_gemma":[0.9739682,0.002038351,0.0007041944,0.0005068345,0.009135101,0.01364734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001131334,0.00005515754,0.000811449,0.0003741287,0.00002889887,0.0004428912,0.001883433,0.0001628059,0.001516075,0.006634322,0.9446253,0.04335233],"study_design_scores_gemma":[0.00001604054,0.00002989608,0.0006460357,0.0003099803,0.00001308258,0.0001177549,0.001487473,0.00006707829,0.0002851579,0.001294633,0.9957088,0.00002390526],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005189711,0.01526035,0.004401856,0.8346427,0.1274772,0.0006297104,0.000387124,0.0001395263,0.01187187],"genre_scores_gemma":[0.1112309,0.03310085,0.03135242,0.5505362,0.05031042,0.001544175,0.002127313,0.00084627,0.2189515],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1012141,"threshold_uncertainty_score":0.2012499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09013228476923313,"score_gpt":0.2968887581965474,"score_spread":0.2067564734273143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}