{"id":"W3032647502","doi":"10.1101/2020.05.28.121806","title":"Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma Reveals Determinants of Poor Prognosis and Response to Immune Checkpoint Inhibitors","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Calgary","funders":"Congressionally Directed Medical Research Programs; National Cancer Institute; National Institutes of Health; Fondation ARC pour la Recherche sur le Cancer; Bristol-Myers Squibb; Dana-Farber Cancer Institute; G. Harold and Leila Y. Mathers Foundation; Leukemia and Lymphoma Society; Dana-Farber/Harvard Cancer Center; U.S. Department of Defense","keywords":"CDKN2A; BAP1; Immune system; Immune checkpoint; Cancer research; Renal cell carcinoma; Biology; Cytotoxic T cell; Immunotherapy; Immunology; Medicine; Melanoma; Gene; Oncology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640106,0.0001653165,0.0002412252,0.0005083854,0.0001550196,0.0004102622,0.0001165377,0.0001756816,0.001928188],"category_scores_gemma":[0.000253231,0.00007199093,0.0002111762,0.0002659203,0.0001509458,0.0001307551,0.0001303179,0.0003324008,0.0004738039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066819,"about_ca_system_score_gemma":0.0003102755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007919552,"about_ca_topic_score_gemma":0.0008403867,"domain_scores_codex":[0.9998422,0.00002733025,0.00001183807,0.00003260867,0.0000494717,0.00003656839],"domain_scores_gemma":[0.9998491,0.00002706127,0.00004572672,0.00002032401,0.0000188402,0.00003894595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001721311,0.000422977,0.07290555,0.00008020774,0.00008755528,0.0002443131,0.00006421565,0.0006703142,0.9066801,0.0003085078,0.0007602648,0.01605454],"study_design_scores_gemma":[0.0001875001,0.0026344,0.5734854,0.00001049818,0.0001027223,0.002233467,0.0001866452,0.003860703,0.4101534,0.0002820141,0.006847013,0.00001629692],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964697,0.0005309727,0.000572741,0.00006524289,0.00001000344,0.00003032587,0.001025784,0.00002618819,0.001269012],"genre_scores_gemma":[0.994983,0.0003469431,0.001117824,0.00004602366,0.00001291538,0.00003907199,0.002152379,0.00001238542,0.001289435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928188,"threshold_uncertainty_score":0.006450415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234475155772167,"score_gpt":0.2252675138658753,"score_spread":0.2129227623081537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}