{"id":"W3032670758","doi":"10.1016/j.str.2020.05.005","title":"Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling","year":2020,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Austrian Science Fund; RYR-1 Foundation","keywords":"SH3 domain; Biology; Skeletal muscle; Coupling (piping); Biophysics; Genetics; Chemistry; Kinase; Proto-oncogene tyrosine-protein kinase Src; Endocrinology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004809418,0.0007474294,0.0005423367,0.0005089646,0.0006690058,0.0006380444,0.0008397048,0.001528444,0.006362241],"category_scores_gemma":[0.0007463234,0.0003181945,0.0008873562,0.0006489939,0.001010609,0.0002604071,0.0005053325,0.001310025,0.001975166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001040988,"about_ca_system_score_gemma":0.0006948076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005754632,"about_ca_topic_score_gemma":0.007067302,"domain_scores_codex":[0.9994574,0.0001643426,0.0001001667,0.00008824773,0.0001019704,0.0000878534],"domain_scores_gemma":[0.9989902,0.0003409408,0.000263657,0.00008921499,0.00008776812,0.0002282066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001968428,0.0001573554,0.001744703,0.00006771284,0.0001294118,0.001379129,0.0001027606,0.001083883,0.9885744,0.001186928,0.0007163192,0.002888931],"study_design_scores_gemma":[0.0008384786,0.000891285,0.03406107,0.0001189859,0.000550084,0.007328201,0.0003664609,0.01959082,0.923628,0.001051683,0.01137313,0.0002018759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925271,0.0004947145,0.003377644,0.0003971301,0.0001883729,0.00004335533,0.001256859,0.0001733884,0.001541373],"genre_scores_gemma":[0.9964949,0.0001009993,0.001190441,0.000230195,0.00003173982,0.0000265692,0.0005157039,0.0001449537,0.00126436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006362241,"threshold_uncertainty_score":0.02128381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600075511913987,"score_gpt":0.2580317078263289,"score_spread":0.2420309527071891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}