{"id":"W3032670758","doi":"10.1016/j.str.2020.05.005","title":"Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling","year":2020,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Austrian Science Fund; RYR-1 Foundation","keywords":"SH3 domain; Biology; Skeletal muscle; Coupling (piping); Biophysics; Genetics; Chemistry; Kinase; Proto-oncogene tyrosine-protein kinase Src; Endocrinology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002603409,0.00007749397,0.00006346518,0.00002575196,0.00005270342,0.00002092965,0.00002561224,0.0000622181,0.00002921111],"category_scores_gemma":[0.00006888848,0.00006728934,0.00001229614,0.0000839996,0.00002184869,0.00001295098,0.0000109685,0.00009107186,0.000001322056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001179324,"about_ca_system_score_gemma":0.00002387277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002239818,"about_ca_topic_score_gemma":0.0001945008,"domain_scores_codex":[0.9995703,0.00001483374,0.00008100542,0.0001949358,0.00005743932,0.000081513],"domain_scores_gemma":[0.9997922,0.00001271537,0.00004437807,0.00006080698,0.00004414118,0.00004575468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003557971,0.000008557885,0.01805785,0.00002437379,0.00002360505,0.000004246563,0.000410192,0.01551429,0.964228,0.0000684546,0.0001977154,0.00110695],"study_design_scores_gemma":[0.005848765,0.0009802745,0.5107681,0.00009742018,0.00005546644,0.0001790741,0.002637617,0.3200505,0.1435069,0.0003691949,0.01464012,0.0008666781],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914492,0.00003925338,0.007745369,0.0003753658,0.0001578883,0.0001354311,0.00002305793,0.0000113445,0.00006313538],"genre_scores_gemma":[0.9988982,0.00001226081,0.0004390873,0.0002048876,0.0002304002,0.000005637124,0.0001511832,0.000008965978,0.00004939747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8207211,"threshold_uncertainty_score":0.274398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600075511913987,"score_gpt":0.2580317078263289,"score_spread":0.2420309527071891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}