{"id":"W3032800512","doi":"10.1200/jco.2020.38.15_suppl.1000","title":"KEYNOTE-355: Randomized, double-blind, phase III study of pembrolizumab + chemotherapy versus placebo + chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Merck","keywords":"Medicine; Gemcitabine; Carboplatin; Internal medicine; Taxane; Pembrolizumab; Oncology; Chemotherapy; Breast cancer; Cancer; Cisplatin; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004625896,0.000448049,0.005302915,0.0001897234,0.00009052134,0.00002484044,0.000401663,0.0003397372,0.001113326],"category_scores_gemma":[0.001634668,0.0002765015,0.001376776,0.0005868929,0.0004876258,0.0001823588,0.00003425664,0.000940792,0.000002707253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004166704,"about_ca_system_score_gemma":0.004436716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003191735,"about_ca_topic_score_gemma":0.0002946912,"domain_scores_codex":[0.9923244,0.001065386,0.005007742,0.0004852424,0.0006537389,0.0004635545],"domain_scores_gemma":[0.9884169,0.00521748,0.004230204,0.000299235,0.001265728,0.0005705287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8035804,0.009365316,0.00011206,0.0001428492,0.008958656,0.0001060263,0.002649546,0.00004429973,0.0002290453,0.000005452338,0.00305346,0.1717529],"study_design_scores_gemma":[0.8843974,0.1028555,0.000198518,0.0002532456,0.002815286,0.0001359283,0.001536135,0.001140231,0.0007152423,0.0000162805,0.005692683,0.0002435034],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675404,0.00152827,0.00107088,0.01955591,0.001721698,0.008295908,0.00005806982,0.00002989944,0.0001989657],"genre_scores_gemma":[0.9828848,0.00888327,0.001503816,0.004747955,0.001249671,0.0003054433,0.00001267482,0.00008007232,0.0003322719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1715094,"threshold_uncertainty_score":0.9999687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1757267021781145,"score_gpt":0.4856334559244245,"score_spread":0.30990675374631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}