{"id":"W3032805488","doi":"10.1002/jcp.29822","title":"Concomitant blockade of A2AR and CTLA‐4 by siRNA‐loaded polyethylene glycol‐chitosan‐alginate nanoparticles synergistically enhances antitumor T‐cell responses","year":2020,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tabriz University of Medical Sciences; Iran National Science Foundation","keywords":"Cytotoxic T cell; Cancer research; Chemistry; T cell; Small interfering RNA; Gene silencing; Immune checkpoint; Tumor microenvironment; Cell biology; Immune system; Immunotherapy; Transfection; Immunology; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645105,0.0002019126,0.0004862686,0.00004529827,0.00005900294,0.0000134249,0.0002594523,0.0001437188,0.00002837949],"category_scores_gemma":[0.0002092118,0.0001674696,0.0001413507,0.00009552967,0.0002715233,0.000009841619,0.0001107718,0.0001860157,0.000001693644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003918067,"about_ca_system_score_gemma":0.0001160012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005998937,"about_ca_topic_score_gemma":1.204359e-7,"domain_scores_codex":[0.9984834,0.0002289487,0.0006040858,0.0002583851,0.0001638299,0.0002614082],"domain_scores_gemma":[0.9989087,0.0001074966,0.0005248337,0.0001532332,0.0001150594,0.0001906688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001387049,0.0001095763,0.0001039717,0.00007217313,0.0001036788,0.00004997353,0.00008130761,0.00007064618,0.9963071,0.00003993921,0.001616096,0.00005842725],"study_design_scores_gemma":[0.001120575,0.001912741,0.0002346543,0.00002856462,0.00008031374,0.00004858988,0.0001115665,0.00006909504,0.9936001,0.0001078238,0.00250608,0.0001798708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824399,0.01533076,0.001174613,0.0007662515,0.0001062415,0.00007373027,0.00002336302,0.000004819941,0.00008029374],"genre_scores_gemma":[0.9979197,0.000759877,0.0004791046,0.0003247356,0.0004220307,0.000001574989,0.00001184974,0.00002130189,0.00005983732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01547977,"threshold_uncertainty_score":0.6829211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039119727801572,"score_gpt":0.2219460375799908,"score_spread":0.2139069178521893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}