{"id":"W3032805488","doi":"10.1002/jcp.29822","title":"Concomitant blockade of A2AR and CTLA‐4 by siRNA‐loaded polyethylene glycol‐chitosan‐alginate nanoparticles synergistically enhances antitumor T‐cell responses","year":2020,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tabriz University of Medical Sciences; Iran National Science Foundation","keywords":"Cytotoxic T cell; Cancer research; Chemistry; T cell; Small interfering RNA; Gene silencing; Immune checkpoint; Tumor microenvironment; Cell biology; Immune system; Immunotherapy; Transfection; Immunology; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145552,0.0004111714,0.0002688973,0.0001739865,0.00007840559,0.0002124143,0.0001836331,0.0003080087,0.0004819653],"category_scores_gemma":[0.0001018126,0.0001366992,0.0002661354,0.0001093781,0.0001775613,0.0001972209,0.0001386443,0.0004424291,0.0001749701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002938843,"about_ca_system_score_gemma":0.0002285154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006985026,"about_ca_topic_score_gemma":0.001065675,"domain_scores_codex":[0.9998574,0.00001735921,0.00001454492,0.00002694767,0.00004127468,0.00004250783],"domain_scores_gemma":[0.9999447,0.000009848638,0.00001589645,0.000005810314,0.00001088591,0.00001292381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007246601,0.00002471624,0.00003410627,0.00002640892,0.000004450891,0.00001177391,0.00000551302,0.0001076021,0.9988872,0.00003030117,0.00002408193,0.0007713112],"study_design_scores_gemma":[0.00001827032,0.0003490633,0.0005493021,0.00000251533,0.00002207343,0.00004335361,0.000005507164,0.001518114,0.9966774,0.00001248723,0.0007987455,0.00000311018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944904,0.001244431,0.002732925,0.00007087144,0.0000451556,0.00003511681,0.00007377368,0.00009563882,0.001211643],"genre_scores_gemma":[0.9957487,0.000581218,0.001762237,0.00004546633,0.00001606188,0.00005277135,0.00008589654,0.00001123374,0.001696495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006985026,"threshold_uncertainty_score":0.002132237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039119727801572,"score_gpt":0.2219460375799908,"score_spread":0.2139069178521893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}