{"id":"W3032832010","doi":"10.2217/fon-2020-0184","title":"Pembrolizumab Given Concomitantly with Chemoradiation and as Maintenance Therapy for Locally Advanced Head and Neck Squamous Cell Carcinoma: KEYNOTE-412","year":2020,"lang":"en","type":"article","venue":"Future Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"Rosetrees Trust; National Institute for Health and Care Research; Cancer Research UK","keywords":"Medicine; Pembrolizumab; Head and neck squamous-cell carcinoma; Head and neck; Oncology; Basal cell; Internal medicine; Head and neck cancer; Radiation therapy; Surgery; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006203996,0.0002071832,0.0006256194,0.0000295546,0.0001112617,0.000009133338,0.0000507655,0.0001567546,0.00001634385],"category_scores_gemma":[0.00005001579,0.0001508236,0.00004037125,0.0001018479,0.0001333874,0.00005824809,0.00002590281,0.0002006631,0.000003672374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105157,"about_ca_system_score_gemma":0.0003279419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000291313,"about_ca_topic_score_gemma":0.0001011159,"domain_scores_codex":[0.9989688,0.00003271138,0.0001930041,0.0003975817,0.0001024553,0.0003054216],"domain_scores_gemma":[0.9992965,0.0001332076,0.0001036954,0.0001192805,0.0001328244,0.0002144521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2485461,0.001380754,0.09401625,0.003297301,0.0004377948,0.001450219,0.04219198,0.00004147838,0.06050072,0.002565554,0.08594459,0.4596272],"study_design_scores_gemma":[0.1044553,0.05747252,0.1251927,0.00008436314,0.0001768659,0.0003680726,0.003338193,0.0006214869,0.004817408,0.0001262953,0.7028363,0.0005103901],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9417488,0.008609402,0.0001708905,0.04350508,0.0001703641,0.001050772,0.00002202169,0.0000496472,0.004673028],"genre_scores_gemma":[0.9866399,0.001045783,0.00210836,0.009101905,0.0007041886,0.0001174182,0.00001772976,0.00003206502,0.0002326197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6168917,"threshold_uncertainty_score":0.615041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139099776184559,"score_gpt":0.2772550983325816,"score_spread":0.2633451207141257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}