{"id":"W3032944184","doi":"","title":"Phosphodiesterase inhibition as an approach to increase chemosensitivity of prostate cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"DU145; Clonogenic assay; Prostate cancer; Zaprinast; Hypoxia (environmental); Phosphodiesterase; Cancer research; Cancer cell; Pharmacology; Cancer; Cell culture; Biology; Chemistry; Medicine; Internal medicine; Enzyme; Biochemistry; LNCaP","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004127698,0.0001223431,0.0001461727,0.00009557311,0.0001987882,0.00001550024,0.00008803778,0.0001048006,0.00005130561],"category_scores_gemma":[0.00008401382,0.0001133894,0.00004678948,0.0003010539,0.0002264339,0.00001504459,0.0001141165,0.0001408673,0.000009902837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007818396,"about_ca_system_score_gemma":0.0003726125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002448223,"about_ca_topic_score_gemma":0.0002171899,"domain_scores_codex":[0.9985825,0.0001686176,0.0001726893,0.0004171792,0.0003544598,0.0003045701],"domain_scores_gemma":[0.9988774,0.00001156869,0.000049296,0.0003320487,0.000510061,0.0002196128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001217169,0.0002470569,0.00550609,0.00005752336,0.00002813007,0.000007613273,0.000719196,0.0004071543,0.9822438,0.00004652505,0.006104713,0.003415017],"study_design_scores_gemma":[0.0006587984,0.0002668057,0.01263668,0.00003707204,0.000005241338,0.00002213003,0.0001610634,0.00007079308,0.9771721,0.00003524243,0.008777239,0.0001567998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970604,0.0004519037,0.0001015252,0.0001910975,0.00009307625,0.0004457271,0.00006620093,0.00001339697,0.001576648],"genre_scores_gemma":[0.9955083,0.0005742256,0.000168754,0.0002974409,0.0002184829,0.0002741238,0.0001687627,0.00002321383,0.002766679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007130586,"threshold_uncertainty_score":0.4623884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04865099144387568,"score_gpt":0.3555614162261616,"score_spread":0.3069104247822859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}