{"id":"W3033006722","doi":"10.1093/ndt/gfaa142.p0068","title":"P0068APABETALONE, A CLINICAL STAGE BET INHIBITOR, REDUCES THE PRO-INFLAMMATORY RESPONSE IN PBMCS FROM FABRY DISEASE PATIENTS ON ERT THERAPY","year":2020,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Resverlogix (Canada)","funders":"","keywords":"Enzyme replacement therapy; Fabry disease; Medicine; Globotriaosylceramide; Inflammation; Peripheral blood mononuclear cell; Fibrosis; Ex vivo; Immunology; Pathology; In vivo; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212145,0.0001896792,0.0003068729,0.0001554189,0.0001284028,0.0002087109,0.0001077437,0.0002064778,0.002634012],"category_scores_gemma":[0.0002388061,0.00006991129,0.0001232793,0.00008640681,0.00007836874,0.00008271947,0.00009788606,0.000397041,0.000435004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008787703,"about_ca_system_score_gemma":0.0001159044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002575441,"about_ca_topic_score_gemma":0.0003494069,"domain_scores_codex":[0.9999149,0.00002407121,0.000007923773,0.00001817461,0.00001713753,0.00001786446],"domain_scores_gemma":[0.9999377,0.00001461597,0.0000106829,0.000003849465,0.000008452737,0.00002468077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02516224,0.00165165,0.01644227,0.0003254629,0.00007636556,0.001002642,0.0002306297,0.0002821868,0.8782184,0.00006763162,0.002686291,0.07385438],"study_design_scores_gemma":[0.008843446,0.07035212,0.5311559,0.000212843,0.0004160512,0.01083247,0.001138873,0.004462887,0.339125,0.0005248203,0.03286166,0.00007396385],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939054,0.002954297,0.000502452,0.000198787,0.00007397044,0.00006725983,0.0005699187,0.00004940782,0.001678576],"genre_scores_gemma":[0.9959896,0.000643723,0.0005892974,0.0002666812,0.00004335767,0.00009025086,0.0007184849,0.000005719494,0.001652883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002634012,"threshold_uncertainty_score":0.008811653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03895581453922042,"score_gpt":0.3231616461064531,"score_spread":0.2842058315672327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}