{"id":"W3033065537","doi":"10.1016/j.bone.2020.115472","title":"Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors","year":2020,"lang":"en","type":"review","venue":"Bone","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; European Research Council; AFM-Téléthon; French Muscular Dystrophy Association; Wellcome Trust; Innovative Medicines Initiative; Hartstichting; Meso Scale Diagnostics; Cancer Genomics Centre; ZonMw; Boehringer Ingelheim; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Nederlandse Federatie van Universitair Medische Centra; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Novartis Pharma; Canada Foundation for Innovation; Ontario Genomics Institute; Novartis; Vetenskapsrådet; Pfizer","keywords":"BMPR2; Bone morphogenetic protein receptor; Bone morphogenetic protein; Cell biology; Signal transduction; Kinase; SMAD; Receptor; Phosphorylation; Activin receptor; Biology; Endoglin; Cell signaling; Cancer research; Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009149262,0.0003579713,0.000931928,0.0001562268,0.000145787,0.00003512662,0.00004733663,0.0004761959,0.00025025],"category_scores_gemma":[0.0001553377,0.0002932038,0.0001915771,0.0004031523,0.00007179234,0.00002982533,0.00003867839,0.0008579607,0.00007668622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123282,"about_ca_system_score_gemma":0.0002191495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001291184,"about_ca_topic_score_gemma":0.00000119393,"domain_scores_codex":[0.9982868,0.0001797698,0.0005794253,0.0005381314,0.0001809225,0.0002349181],"domain_scores_gemma":[0.9991095,0.00003016584,0.0003017073,0.0002162422,0.00008036035,0.0002620044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000424923,0.0002231355,0.0000079338,0.01096797,0.0006171878,0.0001141817,0.0001634932,1.66691e-7,0.01610305,0.0001405394,0.01988291,0.9517369],"study_design_scores_gemma":[0.0005391291,0.0002386775,0.000005500533,0.003438632,0.0008822489,0.0001023189,0.00002472982,0.000008526838,0.00102808,0.000039251,0.993398,0.0002949529],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005185367,0.9957392,0.0001867275,0.0002346363,0.0002001373,0.002588632,0.00009346672,0.0001039423,0.0003347733],"genre_scores_gemma":[0.001505903,0.9922429,0.0006596354,0.0001721329,0.0004855416,0.0004633089,0.001598506,0.0001033381,0.002768776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.973515,"threshold_uncertainty_score":0.999952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181909919407304,"score_gpt":0.2610062897518836,"score_spread":0.2428152978111532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}