{"id":"W303309386","doi":"10.1016/b978-0-12-397933-9.00020-5","title":"Somatic Hypermutation","year":2014,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Somatic hypermutation; Cytidine deaminase; Biology; Antibody; Base excision repair; Activation-induced (cytidine) deaminase; Somatic cell; Mutation; Genetics; Cytidine; DNA; Antigen; Molecular biology; Gene; DNA repair; Enzyme; Biochemistry; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002249912,0.0007383054,0.0004355249,0.0008844151,0.0003651108,0.001213509,0.0005473241,0.001000373,0.06917666],"category_scores_gemma":[0.0002367881,0.0002209773,0.0003073768,0.0008811745,0.0005375745,0.0009810911,0.001025472,0.001328455,0.04213358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004136825,"about_ca_system_score_gemma":0.0003551317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003734035,"about_ca_topic_score_gemma":0.0006369104,"domain_scores_codex":[0.9998046,0.0000173195,0.000007769775,0.00005028852,0.00009683036,0.00002339037],"domain_scores_gemma":[0.9999381,0.00001780712,0.000006795532,0.00001307241,0.00001142934,0.00001273339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000470647,0.00005533035,0.0001816551,0.0002699178,0.0000133141,0.000258966,0.00007313427,0.0003273396,0.04415112,0.03388917,0.05641116,0.8643218],"study_design_scores_gemma":[0.000008586112,0.00004540914,0.0005585411,0.0001070704,0.00001012269,0.001016734,0.0000217821,0.0002749318,0.01785251,0.0134092,0.9666842,0.00001093798],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.008920537,0.04106595,0.02433258,0.001493196,0.00182001,0.00006622721,0.000628393,0.00153247,0.9201407],"genre_scores_gemma":[0.02952453,0.01814578,0.008595553,0.001160364,0.0004136337,0.00008891096,0.0008162917,0.0003480338,0.9409069],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.06917666,"threshold_uncertainty_score":0.231419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176890228071342,"score_gpt":0.2129139347011649,"score_spread":0.2011450324204515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}