{"id":"W3033096949","doi":"10.1007/s10528-020-09953-2","title":"Endothelial Nitric Oxide Synthase Gene Polymorphisms (− 922A > G, − 786 T > C, Intron 4 b/a VNTR and 894 G > T) and Essential Hypertension: An Association Study with Haplotypes Analysis","year":2020,"lang":"en","type":"article","venue":"Biochemical Genetics","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Hormozgan University of Medical Sciences","keywords":"Haplotype; Enos; Biology; Essential hypertension; Genetics; Genotype; Genotyping; Polymorphism (computer science); Population; Nitric oxide synthase; Restriction fragment length polymorphism; Internal medicine; Nitric oxide; Molecular biology; Gene; Endocrinology; Blood pressure; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005171512,0.0005939215,0.0004714437,0.0006245078,0.0006437764,0.0002857649,0.0003510331,0.0005343813,0.002119198],"category_scores_gemma":[0.0007814133,0.0003860236,0.0004153914,0.0008069751,0.0003767641,0.0002237705,0.0002329059,0.0006105449,0.0002439568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001742525,"about_ca_system_score_gemma":0.0002423229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003568267,"about_ca_topic_score_gemma":0.003104882,"domain_scores_codex":[0.9995356,0.0001719482,0.00003892208,0.000143179,0.00005391112,0.00005648398],"domain_scores_gemma":[0.9995167,0.0001427565,0.00007730371,0.00004440254,0.00003891518,0.0001798516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005490895,0.001807668,0.9415674,0.00003565323,0.0006458571,0.002812046,0.0009363199,0.0003187572,0.03972513,0.0002515716,0.0002578865,0.006150854],"study_design_scores_gemma":[0.000358201,0.00184972,0.9916642,0.00001211822,0.0003689349,0.002735747,0.0003253836,0.0008396365,0.001171962,0.0001967065,0.0004556307,0.00002180966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994383,0.00003832921,0.0001891149,0.0000181182,0.000007034363,0.000009090963,0.00007399677,0.000001851269,0.0002241439],"genre_scores_gemma":[0.9991052,0.00003256516,0.0002332875,0.00002053387,0.00001149715,0.00001055387,0.0000847054,0.000003133614,0.000498399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003568267,"threshold_uncertainty_score":0.007094979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176102396884218,"score_gpt":0.2314679633473046,"score_spread":0.2197069393784624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}