{"id":"W3033096949","doi":"10.1007/s10528-020-09953-2","title":"Endothelial Nitric Oxide Synthase Gene Polymorphisms (− 922A > G, − 786 T > C, Intron 4 b/a VNTR and 894 G > T) and Essential Hypertension: An Association Study with Haplotypes Analysis","year":2020,"lang":"en","type":"article","venue":"Biochemical Genetics","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Hormozgan University of Medical Sciences","keywords":"Haplotype; Enos; Biology; Essential hypertension; Genetics; Genotype; Genotyping; Polymorphism (computer science); Population; Nitric oxide synthase; Restriction fragment length polymorphism; Internal medicine; Nitric oxide; Molecular biology; Gene; Endocrinology; Blood pressure; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002286379,0.00035759,0.0007370002,0.0001973579,0.0001118344,0.00006987912,0.000120085,0.0002380737,0.00003868163],"category_scores_gemma":[0.0003584672,0.0002911901,0.000107606,0.0007482375,0.0001114267,0.00005775156,0.0001233438,0.0002536432,0.00001395129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007264501,"about_ca_system_score_gemma":0.00008019993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004948233,"about_ca_topic_score_gemma":0.00001090353,"domain_scores_codex":[0.9976872,0.0001350895,0.0004048522,0.0007362894,0.0006165858,0.0004200232],"domain_scores_gemma":[0.9984834,0.000196791,0.0001808242,0.0003652077,0.0001718353,0.00060198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001000134,0.000505113,0.1148155,0.00003980833,0.0009269599,0.0001531934,0.0001719325,0.00001769825,0.8809723,0.00000277899,0.0003693777,0.00102527],"study_design_scores_gemma":[0.01051623,0.003805876,0.2321086,0.00004810745,0.01210458,0.0001433157,0.000312793,0.009502276,0.7298399,0.00002680148,0.0006486664,0.0009428224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958276,0.002269533,0.000410723,0.0006622295,0.00004120234,0.0006011862,0.00005138265,0.0001035026,0.00003266241],"genre_scores_gemma":[0.995186,0.0004103711,0.00279449,0.000631797,0.0007216514,0.00002221447,0.00008414451,0.00005664431,0.00009264032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1511324,"threshold_uncertainty_score":0.999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176102396884218,"score_gpt":0.2314679633473046,"score_spread":0.2197069393784624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}