{"id":"W3033121377","doi":"10.3389/fcell.2020.00435","title":"Role of Altered Metabolic Microenvironment in Osteolytic Metastasis","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Bone health and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Institutes of Health Research","keywords":"Osteoclast; Cancer cell; Bioenergetics; Osteolysis; Bone metastasis; Cancer research; Metastasis; Bone resorption; Cancer; Tumor microenvironment; Chemistry; Cell biology; Biology; Internal medicine; Endocrinology; Medicine; Mitochondrion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000277002,0.0005597685,0.0009153682,0.001389195,0.0002021317,0.0007304664,0.0005154538,0.0007945994,0.003566035],"category_scores_gemma":[0.0003911559,0.0001767411,0.0004388171,0.001133745,0.0003154014,0.0007147875,0.0004976952,0.001175866,0.001360702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005032622,"about_ca_system_score_gemma":0.000882033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009166411,"about_ca_topic_score_gemma":0.001740458,"domain_scores_codex":[0.999905,0.00001683121,0.0000132915,0.00001691541,0.0000350087,0.00001280101],"domain_scores_gemma":[0.9998888,0.00004807012,0.00001709147,0.000003209279,0.00003033184,0.0000125965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001317404,0.00009295259,0.0002337731,0.02812906,0.0001270773,0.0003125706,0.00006769408,0.0004941147,0.004309649,0.005984268,0.029839,0.9302781],"study_design_scores_gemma":[0.00002764711,0.0001618204,0.001351483,0.004450246,0.0001439762,0.001709561,0.00005575504,0.0001253897,0.0009153082,0.002835659,0.9882041,0.0000190333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001493451,0.9985089,0.0000888646,0.0001962835,0.0001211329,0.000003412488,0.00002267754,0.000006863203,0.0009024538],"genre_scores_gemma":[0.00101293,0.9982034,0.0001031544,0.0001435707,0.00006852945,0.000005545935,0.0000305048,0.00000106713,0.0004312939],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003566035,"threshold_uncertainty_score":0.01192957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037830877692893,"score_gpt":0.2751367508081427,"score_spread":0.2547584420312138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}