{"id":"W3033121377","doi":"10.3389/fcell.2020.00435","title":"Role of Altered Metabolic Microenvironment in Osteolytic Metastasis","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Bone health and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Institutes of Health Research","keywords":"Osteoclast; Cancer cell; Bioenergetics; Osteolysis; Bone metastasis; Cancer research; Metastasis; Bone resorption; Cancer; Tumor microenvironment; Chemistry; Cell biology; Biology; Internal medicine; Endocrinology; Medicine; Mitochondrion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001085819,0.0003353235,0.002296314,0.0003527555,0.00001794284,0.00000233103,0.0000811723,0.0002628628,0.00005308604],"category_scores_gemma":[0.00001190839,0.0002587385,0.000129556,0.0002372766,0.0001059529,0.00001713895,0.0001082961,0.0002730107,0.00002869326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071437,"about_ca_system_score_gemma":0.000318838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009184628,"about_ca_topic_score_gemma":0.00001505511,"domain_scores_codex":[0.9982426,0.0001276105,0.0007650999,0.0004565816,0.00006921714,0.0003388699],"domain_scores_gemma":[0.9994853,0.00003573149,0.0001940107,0.000111001,0.000004300239,0.0001697066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006862333,0.0001671533,0.01347259,0.003417838,0.000187539,0.00003797134,0.0001657742,1.094878e-8,0.00003110105,0.000003312165,0.0002836246,0.9821644],"study_design_scores_gemma":[0.001568952,0.0001613592,0.001503312,0.001002193,0.0003877297,0.0000674441,0.000182142,0.000001354685,0.0002183694,0.00004927407,0.9946615,0.00019639],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001283245,0.9966478,0.000006198157,0.00002728874,0.0002048537,0.0008932908,0.00007675916,0.000006197572,0.000854396],"genre_scores_gemma":[0.0007954531,0.9841889,0.0142786,0.0001074228,0.00001367317,0.0001556937,0.0003213874,0.00002358459,0.0001153111],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9943779,"threshold_uncertainty_score":0.9999865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037830877692893,"score_gpt":0.2751367508081427,"score_spread":0.2547584420312138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}