{"id":"W3033123873","doi":"10.1016/j.omtn.2020.05.030","title":"CRISPR-Cas13a Inhibits HIV-1 Infection","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Peking Union Medical College; Canadian Institutes of Health Research; Chinese Academy of Medical Sciences; National Natural Science Foundation of China; Chinese Academy of Meteorological Sciences; Ministry of Science and Technology of the People's Republic of China","keywords":"CRISPR; Biology; RNA; Effector; Plasmid; Trans-activating crRNA; Virology; DNA; Gene; Cas9; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007901042,0.000242948,0.0001682688,0.00003775918,0.00007048631,0.00004093865,0.0001758898,0.0001782162,0.00009518776],"category_scores_gemma":[0.00003999738,0.0002502659,0.0001663206,0.0001737772,0.00004396906,0.000004955711,0.00009251487,0.0001452386,0.0001163228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001095219,"about_ca_system_score_gemma":0.00002793343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008654692,"about_ca_topic_score_gemma":0.000001736765,"domain_scores_codex":[0.9988465,0.00004778228,0.0002066302,0.000437043,0.0001675152,0.0002945621],"domain_scores_gemma":[0.9993837,0.000003371331,0.00004527828,0.0003379227,0.00005565037,0.0001740834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006973666,0.00003342812,0.001418865,0.00001249108,0.00007286186,0.00001135201,0.0001565213,0.001030829,0.988314,0.00005239215,0.001835159,0.006992303],"study_design_scores_gemma":[0.0007982292,0.0003512513,0.001967675,0.000006462379,0.0000116768,0.00001490542,0.00001793693,0.0003342901,0.834851,0.00002577756,0.1613352,0.0002856461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8556794,0.001692891,0.1401159,0.000906351,0.000141004,0.0002084723,0.000008682538,0.0000790169,0.001168312],"genre_scores_gemma":[0.9947528,0.0005408074,0.001077919,0.003018746,0.0003150002,0.00002067695,0.00007950759,0.0000722894,0.0001222809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1595,"threshold_uncertainty_score":0.9999949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045312759101866,"score_gpt":0.2709161115900577,"score_spread":0.260462983999039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}