{"id":"W3033123873","doi":"10.1016/j.omtn.2020.05.030","title":"CRISPR-Cas13a Inhibits HIV-1 Infection","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Peking Union Medical College; Canadian Institutes of Health Research; Chinese Academy of Medical Sciences; National Natural Science Foundation of China; Chinese Academy of Meteorological Sciences; Ministry of Science and Technology of the People's Republic of China","keywords":"CRISPR; Biology; RNA; Effector; Plasmid; Trans-activating crRNA; Virology; DNA; Gene; Cas9; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189505,0.0004131077,0.0004269264,0.0003015932,0.000254761,0.0004948138,0.0003479153,0.0005303255,0.002130647],"category_scores_gemma":[0.0002207587,0.0001883244,0.0003515034,0.0001767064,0.000324968,0.0001357962,0.0003285548,0.0009766277,0.0008354162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549584,"about_ca_system_score_gemma":0.0004822391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012757,"about_ca_topic_score_gemma":0.001700565,"domain_scores_codex":[0.9997165,0.00003969958,0.0000260109,0.00005422068,0.0001068653,0.00005666525],"domain_scores_gemma":[0.9998996,0.00002641457,0.00002179827,0.00001674586,0.0000144687,0.00002091981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007215983,0.00003723276,0.0002210836,0.00009690879,0.00001426651,0.00007248096,0.00001407304,0.0003181819,0.9895747,0.000695206,0.000622304,0.008261308],"study_design_scores_gemma":[0.00001520867,0.0001286498,0.001144497,0.0000121197,0.00001418201,0.000322432,0.000008426214,0.002507069,0.9830686,0.0001630696,0.01260916,0.000006552911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8661854,0.01679279,0.07369412,0.0009030205,0.0005762564,0.0004439508,0.002747524,0.003538241,0.0351187],"genre_scores_gemma":[0.959936,0.004426509,0.02026931,0.0002116481,0.00003656545,0.0001549213,0.001054502,0.0001053483,0.01380517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002130647,"threshold_uncertainty_score":0.007127762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045312759101866,"score_gpt":0.2709161115900577,"score_spread":0.260462983999039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}