{"id":"W3033212785","doi":"10.1101/2020.06.08.139436","title":"Rab5 regulates macropinosome closure through recruitment of the inositol 5-phosphatases OCRL/Inpp5b and the hydrolysis of PtdIns(4,5)P <sub>2</sub>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Ariad Pharmaceuticals; Pfizer","keywords":"Phosphatidylinositol; Pinocytosis; Cell biology; Vesicle; Membrane ruffling; Chemistry; Phosphatase; Inositol; Phosphatidylinositol 4,5-bisphosphate; Kinase; Biochemistry; Biology; Membrane; Phosphorylation; Endocytosis; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172039,0.0003353672,0.000142622,0.0002623178,0.0002086301,0.0005536041,0.0002195157,0.0002626179,0.001328322],"category_scores_gemma":[0.0001139844,0.0002263111,0.0002370049,0.0001005106,0.0002246969,0.0002621933,0.0002780114,0.0003447864,0.0006209576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008244708,"about_ca_system_score_gemma":0.0003089666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663509,"about_ca_topic_score_gemma":0.002283428,"domain_scores_codex":[0.9998764,0.0000151909,0.0000130209,0.00002448592,0.00002946954,0.00004149372],"domain_scores_gemma":[0.999936,0.000007023825,0.00002234282,0.000005110804,0.000008738333,0.00002083452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001416076,0.00001882413,0.0005001088,0.00004665304,0.000005019531,0.0001044403,0.00001599202,0.0001087334,0.9972479,0.0003116083,0.00007483271,0.001424275],"study_design_scores_gemma":[0.00001735475,0.00007083768,0.01982594,0.00001142882,0.00002083114,0.000203684,0.00006797778,0.004044831,0.9728124,0.0001261403,0.002792967,0.000005531972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929738,0.001896823,0.002347145,0.0001068103,0.00003139884,0.00002203062,0.000235263,0.0001752854,0.002211427],"genre_scores_gemma":[0.9945502,0.0007342942,0.001072991,0.00004822837,0.000007457944,0.00002573664,0.0003271935,0.000024722,0.003209195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663509,"threshold_uncertainty_score":0.005981922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438053468888517,"score_gpt":0.2090730501052841,"score_spread":0.1946925154163989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}