{"id":"W3033293535","doi":"10.22541/au.159137424.43131317","title":"Salvage chemotherapy after failure of targeted therapy in a child with BRAF V600E low grade glioma","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Dabrafenib; Trametinib; Medicine; Discontinuation; Glioma; Oncology; Chemotherapy; Salvage therapy; Targeted therapy; Internal medicine; Procarbazine; Cancer research; Vemurafenib; Vincristine; Cancer; Cyclophosphamide; Biology; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515765,0.0007455137,0.0009021427,0.001131275,0.001261147,0.000587204,0.000696602,0.002434147,0.001266687],"category_scores_gemma":[0.001231485,0.0003264871,0.0007152512,0.0008425584,0.0008849305,0.000762691,0.0006520107,0.002079885,0.0006024928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001939326,"about_ca_system_score_gemma":0.0008349992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004445281,"about_ca_topic_score_gemma":0.008015417,"domain_scores_codex":[0.9998005,0.00002330653,0.00001885909,0.00003532854,0.00003372114,0.00008834345],"domain_scores_gemma":[0.9993132,0.0001408542,0.0001520237,0.00003934029,0.00003871516,0.000315872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00009259163,0.00005550528,0.01176766,0.0000316954,0.00001236149,0.9817829,0.0001760955,0.0002330786,0.0008767746,0.0002880456,0.0008830968,0.003800346],"study_design_scores_gemma":[0.00002353799,0.0003605697,0.01913983,0.00004125109,0.00003108846,0.9757437,0.0001737765,0.0006542566,0.001436406,0.000351763,0.002028792,0.00001512595],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791315,0.003811372,0.00170861,0.006299374,0.0003552182,0.0001032372,0.0004294583,0.0001419683,0.008019253],"genre_scores_gemma":[0.9940227,0.001779797,0.0009942079,0.001270506,0.0002602227,0.00002430694,0.0002497099,0.0000456317,0.00135302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004445281,"threshold_uncertainty_score":0.01407087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037542361496649,"score_gpt":0.243788563569095,"score_spread":0.2334131399541285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}