{"id":"W3033295541","doi":"10.3390/cells9061398","title":"Conditionally Reprogrammed Cells from Patient-Derived Xenograft to Model Neuroendocrine Prostate Cancer Development","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Mitacs; Canadian Institutes of Health Research; National Cancer Institute; Prostate Cancer Foundation; National Institutes of Health; Terry Fox Research Institute","keywords":"Transdifferentiation; Prostate cancer; Cancer research; Transcriptome; Biology; Androgen receptor; Downregulation and upregulation; Adenocarcinoma; Cancer; Reprogramming; Prostate; LNCaP; Cell; Cell biology; Stem cell; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255038,0.0002564168,0.0002640281,0.000247903,0.0001356499,0.0003236175,0.000254674,0.0003591707,0.00231411],"category_scores_gemma":[0.0001803001,0.0001752785,0.0003287582,0.0001952619,0.0001845632,0.0001640052,0.000272782,0.001168969,0.0008297185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066586,"about_ca_system_score_gemma":0.0002340912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005480784,"about_ca_topic_score_gemma":0.0006914031,"domain_scores_codex":[0.9997064,0.0000388507,0.00004018844,0.00007829016,0.00009155833,0.0000446982],"domain_scores_gemma":[0.9998003,0.00003718569,0.00004200199,0.00004918014,0.00002033993,0.00005104249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008043504,0.00007204075,0.0003572852,0.00004067353,0.00000701202,0.0001324487,0.0000547163,0.0002609363,0.9967465,0.0003577259,0.0001881044,0.001702087],"study_design_scores_gemma":[0.00004803146,0.001083048,0.005848116,0.0000173185,0.00003771823,0.001524773,0.00007894263,0.004245907,0.9702604,0.0001178741,0.01672148,0.00001639262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732906,0.0008463375,0.01705134,0.0001676475,0.0001165226,0.0003703623,0.003667155,0.0004125086,0.004077423],"genre_scores_gemma":[0.978721,0.0007442574,0.00883817,0.0001159552,0.00001451486,0.0003076117,0.004300095,0.0001144688,0.006843865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00231411,"threshold_uncertainty_score":0.007741511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0385939187859812,"score_gpt":0.2954363787399885,"score_spread":0.2568424599540072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}