{"id":"W3033322261","doi":"10.1016/j.mce.2020.110865","title":"Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation","year":2020,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Carleton University; Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health","keywords":"PI3K/AKT/mTOR pathway; Phosphorylation; Mechanistic target of rapamycin; Decidua; Cell biology; RPTOR; Biology; Signal transduction; mTORC1; Endocrinology; Internal medicine; Chemistry; Placenta; Medicine; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023938,0.000338417,0.0003736218,0.0003533586,0.0003451754,0.0004406258,0.0002555365,0.0002214945,0.002993055],"category_scores_gemma":[0.0001835581,0.0002472774,0.0004209318,0.0001670066,0.0004101455,0.0002340517,0.0002841425,0.001013737,0.000474657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006821657,"about_ca_system_score_gemma":0.0006534664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002873385,"about_ca_topic_score_gemma":0.005100934,"domain_scores_codex":[0.999744,0.00003346277,0.00002001972,0.00004470751,0.000054665,0.0001031444],"domain_scores_gemma":[0.9998891,0.00002268116,0.0000197295,0.0000104273,0.00001223937,0.00004564599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001896335,0.00006467917,0.0003650971,0.0001537143,0.00001382726,0.000137331,0.00003935449,0.00004502935,0.9927915,0.0002722801,0.0003545845,0.003866286],"study_design_scores_gemma":[0.00009519367,0.000410975,0.02416255,0.00001716727,0.00003247424,0.0003583292,0.0001247147,0.0006320364,0.9657114,0.0001410886,0.00830422,0.000009938688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703161,0.01352875,0.004191707,0.001189188,0.0005311189,0.00009016539,0.00220386,0.0003063678,0.007642745],"genre_scores_gemma":[0.9832315,0.002935612,0.004369211,0.0004707868,0.00009685622,0.0001647581,0.001625722,0.00004225294,0.007063314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002993055,"threshold_uncertainty_score":0.01001275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302238493923006,"score_gpt":0.2138467542989379,"score_spread":0.2008243693597078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}